Women's "Life Enemies": Dysmenorrhea and the Magic Drug "Ibuprofen"
As an anesthesiologist, in our common visual pain score, the severe dysmenorrhea score can even reach seven to eight points of the total score, which can be said to be very serious. So how does dysmenorrhea happen? How does ibuprofen, a commonly used analgesic, produce analgesic effect?
As we all know, menstruation is 14 days after ovulation. The periodic exfoliation of endometrium is caused by the withdrawal of sex hormones in the body. In this process, due to the destruction of endometrial cells, prostaglandin pgf2a will continue to be released, causing strong contraction of uterine muscles. Prostaglandin here is the culprit of dysmenorrhea. Seeing this, some people may think that prostaglandin only exists in male compatriots, but this is not the case.
Prostaglandin will promote the continuous compression and contraction of uterus to eliminate necrotic endometrium. In this process, the blood supply and nutrition of the surrounding tissues are cut off due to the continuous blunt instrument extrusion, which will lead to ischemia and hypoxia, acid metabolites accumulate in the endometrium, and stimulate nerve endings to produce pain.
More sadly, prostaglandin itself, as an inflammatory factor, tends to cascade and enhance the inflammatory response, and it will continue to release analgesic factors, resulting in more sensitive pain!
At the same time, a large amount of prostaglandin will also accumulate in the lower limbs, abdomen and back, which is the reason why dysmenorrhea sometimes leads to lower back and leg pain.
In addition, prostaglandins may cause many unpleasant experiences to the human body, which will not be described here.
Ok, how to relieve dysmenorrhea? Many girls will mention a "magic", namely ibuprofen.
Women's "enemies in life": dysmenorrhea and the magical drug "ibuprofen"
Ibuprofen itself is a drug that inhibits the release of prostaglandin. Regarding this drug, we will analyze it one by one:
0 1.
First of all, ibuprofen belongs to the NSAID category, which is a non-steroidal antipyretic, analgesic and anti-inflammatory drug. Reduce prostaglandin secretion by inhibiting cyclooxygenase. It is not a central analgesic, so it is not a central analgesic. Addictive.
02.
Secondly, ibuprofen is an over-counted drug, which means that it can be bought in any pharmacy, but you need to pay attention to it when using it. Ibuprofen is metabolized by the liver and excreted by the kidney. Therefore, patients with liver and kidney dysfunction should be used with caution.
03.
Third, ibuprofen is irritating to the gastrointestinal tract. Excessive use can lead to side effects such as nausea and vomiting or stomachache. Therefore, the recommended dose for adults is 400 to 600 mg twice a day with an interval of 6 to 8 hours. Use. Ibuprofen needs to be taken in advance and usually takes effect within half an hour. It is not recommended to use ibuprofen in combination with other analgesics and anti-inflammatory drugs or antibiotics. 04
Fourth, people with the following contraindications should not take ibuprofen: serious gastrointestinal diseases allergic to drugs, such as ulcer bleeding and perforation, pregnancy and lactation.
To sum up, ibuprofen has the characteristics of small side effects, no addiction and quick onset. It is the first-line drug to relieve dysmenorrhea at present.
In addition, I repeat, because ibuprofen is not a central analgesic, there will be no problem of analgesic abuse. Female friends can take it boldly, but it needs to be emphasized that if dysmenorrhea is very serious, painkillers are difficult to relieve. Be sure to go to the hospital to rule out the possibility of secondary dysmenorrhea or severe endometriosis (this disease will be discussed separately at a later stage).
In addition, for some female friends, low-dose estrogen and progesterone perfusion therapy with short-acting contraceptives is also an effective method to relieve dysmenorrhea. You can consult a gynecologist for detailed information.
Perhaps none of us have heard of the word dysmenorrhea, but not everyone knows or understands dysmenorrhea, and even makes women with dysmenorrhea "self-righteous" pretentious, and even sings without illness.
At the same time, there is no so-called western women's health, western women have no dysmenorrhea, and our sisters are very fragile. In the face of dysmenorrhea, women all over the world are in great pain. Women in Europe and America keep making noises, and their slogan is: Dysmenorrhea is abnormal. More and more women and medical experts in the world have also realized this concept.
Therefore, we need to speak, arouse more sympathy and teach more knowledge to relieve dysmenorrhea. For men, do not underestimate dysmenorrhea. It may be the "devil" who tortures your female partner's life; For women, don't be afraid of dysmenorrhea. Modern medicine can relieve pain to the greatest extent. Please go to the doctor without shyness and shyness.