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Picked fist-sized tender pumpkins to eat, some have a bitter flavor, I do not know if I can eat, will be poisonous?
The fist-sized young pumpkins are not poisonous.

Pumpkins undergo a number of changes in the chemicals in the fruit during growth, including an increase in soluble sugars and a shift in other chemicals, which can give different fruits different flavors, not only pumpkins but other fruits as well.

The fist-sized tender pumpkin contains a small amount of bittersweet, slightly bitter flavor, which is normal, but not poisonous, just because such a pumpkin does not have a real pumpkin kind of flavor, so try not to eat too tender.