the format of drug approval number is: national medicine quasi-word +1-digit letter +8-digit number, and the format of drug approval number for trial production is: national medicine trial word +1-digit letter +8-digit number. The letter "H" is used for chemicals, the letter "Z" is used for traditional Chinese medicine, the letter "B" is used for health care drugs rectified in National Medical Products Administration, the letter "S" is used for biological products, the letter "T" is used for in-vitro chemical diagnostic reagents, the letter "F" is used for pharmaceutical excipients, and the letter "J" is used for imported repackaged drugs. Numbers 1 and 2 are the source codes of the original approval number, in which "11" stands for drugs approved by the former Ministry of Health, "19" and "21'" stand for drugs approved by National Medical Products Administration before October 1, 2112, and the other first two digits stand for drugs approved by provincial health administrative departments, using the first two digits of provincial administrative division codes (attached). The third and fourth digits are the last two digits of the year of renewal of the approval number, but the approval number from the Ministry of Health and National Medical Products Administration still uses the last two digits of the original number. Numbers 5 to 8 are sequence numbers.

source: yaozhi. com full-text database of drug standards.