The second generation of the Buendía family consists of two boys and a girl: the oldest, José Alcántio, was born on the road to Macondo, and grew up on the road, stubborn like his father, but not as imaginative as he was; he fornicated with a woman named Pilar Ternella, had a child, but then fell in love with a gypsy woman when the gypsies came to perform in Macondo once, so he chose to to run away; later he returned, but of a ponderous disposition. Finally, despite his family's objections, he marries Rebecca, but is thrown out of the house and eventually shot dead in his home.

The second Aureliano was born in Macondo, in his mother's womb will cry, open-eyed out of the world, from a young age has been endowed with the ability to foresee things, as a teenager, like his father, silent, all day long buried in his father's laboratory to do small goldfish. When he grew up, he fell in love with the young Remedes, the daughter of Macondo Rizzo, who had a son named Aureliano José with his brother's lover. His beautiful wife, who was pregnant with twins, died as a result of being accidentally killed by Amaranda. He later fought in the Civil War and became a colonel. In his life he survived 14 assassinations, 73 ambushes and one execution. When he realized that the war was pointless, he facilitated a peace treaty with the government to stop the war and then shot himself in the heart, but he miraculously survived. He lived in concubinage with 17 foreign women and gave birth to 17 boys. These boys later returned to Macondo unannounced to find their roots, but were hunted down and killed, and a week later, only the oldest survived. Aureliano returned home in his old age and refined gold daily to make small goldfish, making two a day, and when he reached 25, he melted them in a crucible and made them again. He lived a life of isolation and solitude like his father until his death.

The third is the daughter Amaranda, who falls in love with the Italian piano technician Pietro, and becomes involved with the Italian after her love rival Rebecca gives up on the Italian and marries José Alcántio, but then refuses to marry the Italian, who kills himself in response. Out of remorse, she deliberately burns one of her hands and wraps it in a black bandage for the rest of her life, determined never to marry. However, she felt extremely lonely and bitter inside, and even hung out with her nephew, who had just come of age, as a "temporary cure for her illness". However, she could not get rid of her inner loneliness, she shut herself in the room all day long sewing mortuary clothes, sewing and dismantling, dismantling and sewing, until the last moment of life. The fourth generation is a woman and two men born of Alcántio's fornication. The daughter of the beauty of Remedes is beautiful, exudes a disturbing odor, this odor has put several men to death. She is completely unclothed and wears a cloth bag, but she doesn't want to waste her time getting dressed. This unique girl was worldly and transcendent, and finally magically grabbed a snow-white sheet and rode off on the wind, disappearing into the air forever.

Her two brothers, Alcatio the Second and Aureliano the Second, were twins. Alcatio the Second became a labor leader when he worked as a supervisor in an American-run banana company, agitating workers to strike. Later, he led a strike of more than 3,000 workers, which was suppressed by the military and police, and he was the only one of the 3,000 who survived. He witnessed the government transporting the bodies of the workers by train to the beach and throwing them into the sea, and announcing over the radio that the workers had been temporarily transferred to other jobs. Alcántio went around telling the truth about the massacre he had witnessed, but was considered delirious. Frightened and disappointed, he locked himself in his house to study the parchment manuscripts left by the gypsies, and remained in this room until his death.

The second Aureliano, who had no proper occupation, spent his days in a drunken stupor, abandoning his wife, Fernanda, and hanging out at the home of his mistress, Petra. Strangely enough, whenever he lived with his mistress, his livestock multiplied rapidly, bringing him wealth, and once he returned to his wife, the family business was in ruins. He had two daughters and a son with his wife, and finally died in sickness at the same time as Alcántio, and from birth to death, people never recognized who the two brothers were. The fifth generation of the Buendía family were the two daughters and one son of the second Aureliano. The eldest son, José Alcántio, was sent as a child to study at the seminary in Rome, where his mother hoped that he would become a bishop, but he had no interest in this, and lied to his mother that he was at the seminary for the sake of an imaginary inheritance. After his mother's death, he returned home and sold the family business for a living. He later found more than 7,000 gold coins that Ursula had hidden in a cellar, and from then on led an even more debauched life, and was soon killed by thugs who robbed him of the coins.

Renata Remedes (Mui Mui), the eldest daughter, falls in love with Maurishaw Babylon, a mechanic at the banana company's car garage. Her mother forbids them from seeing each other, so they have to meet secretly in the bathroom, where her mother discovers that her daughter has been forbidden to go out and hires a bodyguard to guard the house. Mawrishaw Babylon climbed onto the roof of Mame's house and was shot in the back by the bodyguard. He became bedridden, and died of old age in solitude, thought to be a chicken thief. Meimei is devastated. Her mother, believing in family scandal, sent her pregnant to a convent and never spoke a word for the rest of her life.

The youngest daughter, Amaranda Ursula, went to school in Brussels, where she became involved with Gaston, a pilot, and returned to Macondo, where she saw the devastation and was determined to rebuild her home. She was a vibrant and energetic woman who transformed her home in just three months. Her arrival brought to Macondo the most extraordinary person, who was in a better mood than anyone in the family and who wanted to send all the stereotypes to the 18th circle of hell. She decided to settle down and save the village and town from this catastrophe. The sixth generation of the Buendia family is Aureliano Buendia, an illegitimate son sent back by Meme. He was born and raised in solitude. His only hobby is to hide in the rooms of the Gypsy Melquiades and study various mystical books and manuscripts. He was able to converse with the old Gypsy Melquiades, who had been dead for many years, and was instructed to learn Sanskrit. He has been indifferent to the world around him, but is well versed in medieval learning. He and José Alcántio refuse to take in the only surviving elder of Aureliano's 17 sons, resulting in his being shot dead by the men who are pursuing him. He unknowingly falls in love with his aunt Amaranda Ursula and has an incestuous relationship, and despite the loneliness and love they suffer, they believe that they are, after all, the single happiest people on earth. Later Amaranda Ursula gives birth to a boy: "He was the only baby born in a hundred years of the Buendi Adam who had been conceived as a result of love," yet he had a pig's tail on him. Amaranda Ursula also died of a postpartum hemorrhage.

The boy with the pig's tail was the seventh-generation heir to the Buendia family. He was eaten by a swarm of ants at birth. When Aureliano Buendia saw his son, who had been eaten by ants with only a small piece of skin left, he finally deciphered the manuscript of Melquiades. The inscription at the beginning of the manuscript volume reads, "The first of the family will be tied to a tree, the last of the family is being eaten by ants." As it turns out, it is the history of the Buendia family that is recorded in this manuscript. The moment he finished the last chapter, a sudden hurricane blew the whole town of Macondo off the face of the earth, and the village disappeared forever.