1, sulfonylurea drugs (glipizide): glucose-lowering mechanism is to promote pancreatic β-cell secretion of insulin, adapted for dietary control and physical exercise for 2-3 months unsatisfactory results in mild and moderate type 2 diabetes mellitus patients, the general recommended dose of 2.5-20mg / day, taken 30 minutes before meals. Daily dose more than 15mg, it is advisable to take in the morning, midday and evening before three meals. When using sulfonylureas for obese people, special attention should be paid to dietary control, so that weight loss is gradual, and it is better to be used in combination with biguanide (metformin) or alpha-glucosidase inhibitor (acarbose) glucose-lowering drugs.
2, biguanide glucose-lowering drugs (metformin): the main mechanism of hypoglycemia is to increase the utilization of glucose in peripheral tissues, increase the anaerobic fermentation of glucose, reduce the absorption of glucose in the gastrointestinal tract, and reduce body weight. It is suitable for patients with type 2 diabetes mellitus who are not satisfied with simple dietary control, especially obese people, with this class of drugs not only has the effect of hypoglycemia, but also may have the effect of reducing body weight. Combined with sulfonylurea hypoglycemic drugs, there is a synergistic effect, better than their respective effects. Generally start with 250mg twice a day. Take it with or after meals, and then adjust the dose gradually depending on the condition. The maximum daily dose should not exceed 2.5g.
3,
Alpha glucosidase inhibitor (acarbose):
Oral hypoglycemic drugs to treat diabetes by slowing the absorption of intestinal carbohydrates.
These drugs are available for both type 1 and type 2 diabetes, and can be used in conjunction with sulfonylureas, bis(guanethidine), or insulin.
4,insulin sensitizers (pioglitazone) : Enhance insulin sensitivity, promote the full utilization of insulin, so as to achieve the stimulation of glucose absorption in the body, thus lowering blood glucose.
For the treatment of type 2 diabetes. Pioglitazone can be used alone, or in combination with sulfonylureas, metformin, or insulin when dietary control, physical activity, and monotherapy do not satisfactorily control blood glucose. Adults administer pioglitazone orally 15 to 30 mg per dose once a day before or after breakfast. If patients experience symptoms of hypoglycemia when this product is combined with an insulin secretion enhancer such as glipizide, the dose of the insulin secretion enhancer drug should be reduced.
Combined with the above characteristics of the drug, according to your description, we can see that you use the drug is not very reasonable, the drug is too much, resulting in too strong hypoglycemic effect, hypoglycemia before lunch and dinner, which is very dangerous. Low blood sugar can be fatal. Drug adjustment, give you the following suggestions:
1, metformin tablets 0.25g, three times a day, 1 tablet each time, take in the meal;
2, glipizide tablets 5mg, twice a day, half a tablet each time, 30 minutes before breakfast, dinner;
3, pioglitazone tablets 15mg, once a day, one tablet each time, before or after breakfast;
3, pioglitazone tablets 15mg, once a day, one tablet each time, before or after breakfast;
4, with the blood glucose of the blood glucose. p>
4, carry a few candies or chocolates with you, and replenish glucose in time when symptoms of hypoglycemia such as dizziness, nausea, and shortness of breath occur;
5, adjust the above medication in time according to your own diet and blood sugar level.