According to the theory of traditional Chinese medicine, licorice can harmonize the medicinal properties to detoxify; with its sweet taste, it can slow down and moderate the harshness to detoxify; with its sweet taste, it can tonify and strengthen the root to detoxify. Modern medicine shows that licorice sweeteners are decomposed into glycyrrhizic acid and glucuronic acid in the liver after absorption, and the latter can combine with poison to detoxify. Carbon tetrachloride is a typical hepatotoxin, licorice hypochlorous acid can inhibit the generation of carbon tetrachloride free radicals without liver damage, thus licorice has a protective effect on the liver damage caused by carbon tetrachloride, tetrachloroethylene, anti-tuberculosis agent and alcohol. Licorice can also lift the lethal effect of diphtheria toxin, tetanus virus, mixed with snake venom injected into white rats, can defend the lethal effect of snake venom and local necrosis, and its effectiveness even exceeds that of snake venom serum, licorice has a moderate or mild detoxification effect on caffeine, acetylcholine, nicotine and barbiturate.