The so-called five indicators of hepatitis B or "two and a half" are the most commonly used serological detection indicators of hepatitis B, and the same patient may have different detection results in different periods. Analysis of the infectivity of hepatitis B depends not only on whether it is "three positive", but also on whether HBv—DNA is positive and the level of replication, so as to accurately judge the infectivity of hepatitis B. The following briefly introduces the significance of different combinations of five indicators of hepatitis B, as shown in the comparison above.

As the saying goes, "Big Sanyang" refers to the line 1 in the above table, and "Small Sanyang" refers to the line 2 in the above table.

1, "Big Three Yang" can be seen in the following possibilities:

① Chronic hepatitis B, with common symptoms such as fatigue and loss of appetite;

② HBV tolerant carriers have no obvious symptoms, and their liver function and B-ultrasound examination are normal;

③ Early stage of acute hepatitis B;

(4) Hepatitis B cirrhosis is found in a few patients with cirrhosis whose virus is still actively replicating.

2. "Xiao Sanyang" can be found in the following situations:

① After asymptomatic immune clearance, hepatitis B virus-infected people enter the residual period of the virus, forming a "small three-positive" carrier of hepatitis B virus;

② After one or more episodes, patients with hepatitis B changed from "big three yang" to "small three yang", their liver function returned to normal, virus replication gradually stopped, and HBV—DNA was not found in their blood, which belonged to the stage of chronic liver recovery or stability;

③ Hepatitis B virus mutates under the pressure of human immune function. The mutated virus E antigen can't be detected, but the serum anti-—HBe is positive. Although the patient showed "small three yang", his liver function was still abnormal, and most of his HBV-DNA (+) conditions continued to progress. It may be chronic hepatitis B, or a few patients may have developed liver fibrosis or early cirrhosis.

3. Significance of 3.HBv—DNA in the course of hepatitis B: The clinical examination of HBV-DNA quantification is negative if the test result is less than 3.0× 10 cubic meter, or it is indicated by (-), and some test reports are indicated by "0"; If the cubic power is greater than 3.0× 10, it is positive, otherwise it is represented by (+).

① HBV-DNA is a gene fragment at the core of hepatitis B virus, and the blood test of HBV-DNA (+) shows that the virus is replicating in large quantities and is highly contagious.

② Although HBv-DNA (+) is a "big three-positive" in patients with chronic asymptomatic HBv carriers, it does not mean that the condition is serious, because there is no immune response or hepatocyte necrosis in the virus tolerance stage.

Patients with CHB, such as HBV-DNA (+), indicate that the disease may continue to develop, or there is hepatocyte necrosis, so check for abnormal liver function; If the change of HBV—DNA to (-) after treatment is a sign of improvement, the condition may be stable for a long time and will not develop. However, a small number of patients can change from (-) to (+), leading to disease recurrence.

④ Antiviral drugs can reduce the HBv—DNA index of patients with chronic hepatitis B, which is a sign of effective clinical treatment. In a word, it is an ideal curative effect to keep HBV-DNA (-) continuously. If HBV-—DNA remains (-) in patients with liver cirrhosis for a long time, the disease may not develop again.