Small reddish papules around the glans at the coronal sulcus of penis. ? It often occurs in young people and adults, usually in their 2 s and 4 s. 1% of normal people will have it, which is more common in young people with long foreskin and masturbation habits. ? Generally, there is no conscious symptom, and it is often found suddenly after bathing or unclean sexual intercourse, which is easily misdiagnosed as condyloma acuminatum.

There are different reports on the incidence of penile pearl papules. It is reported abroad that this disease is 8.3%-3.1% in normal male population. The survey results of different medical institutions in China are different. Among 239 men (excluding phimosis and sexually transmitted diseases), 159 cases were found in an A institution, and the incidence rate was 66.53%. A B institution found 22 cases out of 917 cases, with an incidence rate of 24%. A C institution found 786 cases among 237 young men who underwent premarital physical examination, with an incidence rate of 37.92%. A D institution investigated 276 cases in STD clinic, and found 19 cases, with an incidence rate of 39.49%. These findings indicate that penile pearl papules are a common disease in clinic.

The main points of differential diagnosis between penile pearl papule and condyloma acuminatum are that the former is a pearl milky papule with a smooth surface, and the damage is limited to the edge of glans penis, and the acetic acid test is negative. However, the damage of the latter is not limited to the edge of the glans penis, but mostly scattered. The damage is large, the surface is not smooth, and it is mostly cauliflower-like. It gradually increases with the course of the disease, and the acetic acid test is positive. Histopathological examination shows hollow cells.

Penile pearl papule is a benign disease. Some people can disappear after a certain period of time, while others can remain unchanged for decades. Because the disease is not contagious and does not hinder health, it does not need to be treated. However, in order to prevent the aggravation of the disease, it is very important for patients to pay attention to local cleanliness and keep a dry environment. If the patient asks for treatment, he can choose laser therapy, cryotherapy or pearl medicine to remove it, but remember to avoid scar caused by excessive injury and cause the patient's pain. For some patients, it may recur after removing these lesions.