Synephrine is found in many plants, the content is relatively high in Hovenia

Traditionally, the main plant is extracted, first 20 to 1 more, that is, 20 kilograms of dried Hovenia or Hovenia, crushed with water and ethanol extraction, and then dry in the crushing, the method of waste, low content.

After the improvement is, add water to extract the second, the extract is concentrated under reduced pressure? To the relative density of 1.1 or so, add ethanol to the alcohol content of 70% or more, static?12 hours, take the supernatant recovery of ethanol, the concentrate add appropriate amount of water, with sand filter? Column filtration, filtrate added to the cation exchange resin column, first rinsed with appropriate amount of water, ? Then use a certain concentration of ammonia to elute, collect the eluent, low temperature concentration to the appropriate amount, static crystal precipitation. The eluate was collected, concentrated at low temperature to the appropriate amount, static precipitation, filtered, recrystallized, and obtained white crystals of octocrystalline. This method is improved over the previous but the cost is still high.

Currently the mainstream for the chemical synthesis, there are p-hydroxyacetophenone bromination condensation in the reduction, but there are raw material costs are high there is a low yield there is a large investment in equipment, the following is the most cost-effective program, with phenol and chloroacetyl chloride friedel?crafts (acylation reaction)

To get 2 chloro-1-(4-chloroacetyloxyphenyl)ethanone, in the reaction with methylamino alcohol to get 2 chloro-1-(4-chloroacetyloxyphenyl)ethanone, and the reaction with methylamino alcohol to get 2 chloro-1-(4-chloroacetyloxyphenyl)ethanone. After reacting with methylamino alcohol to get 2-methylamino-1-(4-hydroxyphenyl)ethanone into hydrochloride salt and then reduced by potassium borohydride to get octafolin. You can browse the official website of the laboratory under Nanchang Zhongqin Trading Co. Or I send part of the original material pictures to you