Female condyloma acuminatum is common in clitoris, labia majora, perianal region, perineum, vagina and cervix. Most female patients with condyloma acuminatum have symptoms such as pruritus vulvae and increased leucorrhea. In the early stage of female condyloma acuminatum, it started as individual pink fluffy tiny papules, and then gradually increased, tending to be confused or overlapped with each other. The external concavities and convexities were biased in different shapes, such as granulation and pimples. Due to local damp heat and slow stimulation, it often increased rapidly, and it could organize papillary, cauliflower-like and cockscomb-like lesions of different sizes, which were fluffy in nature and easy to bleed when touched. Because secretions infiltrated the outside, it was white, dirty or red, and the roots of warts were narrow and often pedicled.

The symptoms of male condyloma acuminatum mainly occur in prepuce frenum, coronary sulcus, prepuce, urethra, penis, anus and scrotum. At the beginning of the disease, it is reddish or dirty red millet-sized particles, which are soft in nature and slightly pointed at the top, and gradually grow up or increase. The symptoms of condyloma acuminatum can develop into papillary or cystic shape, with a slightly wider or banded base and particles on the surface. Condyloma acuminatum in the anus is often enlarged, like cauliflower, with moist surface or bleeding, and pus often accumulates between particles, giving off a foul smell, which can lead to secondary infection after scratching. Condyloma acuminatum, located in a dry part with low humidity, is often small in damage and flat wart-like. The symptoms of condyloma acuminatum located in hot and humid parts often show filiform or papilloma-like, which is easy to fuse into large masses.