Adult epiphyses are basically closed, and the effect of using heightening drugs is not good. Even if the epiphyses are not closed, you should not use drugs indiscriminately before doing a comprehensive examination. In case the uncovered parts of epiphyses are not in the long bones but in other parts such as the face, or the bilateral epiphyses are not closed symmetrically, abuse of heightening drugs will lead to adverse consequences. What's more, there are many kinds of high-altitude drugs, so it is necessary to find out the physiological reasons for the need for high-altitude drugs first to judge which drugs to choose and which drugs are useful.