①LD50: The oral dose of female and male mice was greater than 10 g/kg(bw).

②Ames test: negative (inspection report of Shanghai Health and Epidemic Prevention Station).

③ Chronic toxicity test: the dosage of this product is 2 g/(kg? d)、 1 g/(kg？ D) Rats were fed orally for 6 months, and their weight changes, food intake, blood, anatomy, organ weight and histology were observed. There is no difference between each sample group and the control group (Japan).

④ Teratogenic test: Feed this product to infertile rats and mice [dose 2 g/(kg? D) and 1 g/(kg? D)], from the 7th day of pregnancy to 14d for 8 consecutive days, measure the weight of the surviving fetus; The appearance, bones, growth and mobility of newborn rats; Check the appearance, internal organs and bones after death. The results showed that there was no difference between fetal rats and newborn rats and the control group (Japan).

Quality requirements: quality standards

Calcium content /% 12.2 1.0

L- aspartic acid ≥ 80.0

The pH value is 6.0~7.5

Moisture /% 4.0~8.0

Heavy metal (calculated as Pb) /% ≤ 0.00 1

As /% ≤ 0.000 1