The choroid plexus is the master of the biological clock and has been recognized by top international journals
Dr. Jihwan Myung, a medical researcher at the Brain and Consciousness Research Center of Shuanghe Hospital, used mouse experiments to discover the master of the body clock The site of the circadian clock is the Choroid Plexus, not the Suprachiasmatic Nucleus as previously known. This discovery not only challenges the past cognition of the academic community, but was also published by the top international journal "Nature Communications" (Nature Communications) affirmed that this research can also be applied to the treatment of stroke, asthma, sleep disorders and other related diseases in the future.
The choroid plexus plays a key role in embryonic and adult neurological development
Dr. Zhizhihuan pointed out that as early as 100 years ago, the choroid plexus was confirmed to produce cerebrospinal fluid (Cerebrospinal Fluid) Main structure. The latest relevant research shows that the choroid plexus plays a key role in embryonic and adult neurological development. It is also a potential key to the clearance of metabolites in the brain, and may even provide new treatment strategies for Alzheimer's disease. The choroid plexus is also a major source of brain cell growth factors. These new findings suggest that the choroid plexus is an indirect regulator of neuronal activity and deserves reassessment.
The biological clock responds to the external environment
Past research has shown that the physiological functions and behaviors of all organisms are cyclical, even in the cells of a single individual , also has its own unique approximately 24-hour biological clock, which can cope with drastic changes in the external environment throughout the day in the most efficient way. Dr. Zhizhihuan said that the mammalian brain is a wonderful place, and there are still many locations and functions that have not been fully discovered. Take the suprachiasmatic nucleus (SCN) as an example. The SCN located in the brain has been considered to be the main biological clock that sends day and night time to other parts of the body, while the choroid plexus that secretes cerebrospinal fluid in the brain only receives signals from the SCN. Areas of the brain that passively receive clock signals.
The choroid plexus dominates the circadian clock
Research by Dr. Zhizhihuan found that animal experiments confirmed that the biological clock in the body starts from the choroid plexus, and the changes in the choroid plexus are very fixed, even It is more stable than the rhythm produced by the suprachiasmatic nucleus; what is even more amazing is that the choroid plexus actually has the ability to actively transmit back and further regulate the speed of the suprachiasmatic nucleus clock, occupying a dominant position in the body's physiological clock.
The circadian clock is related to physiological conditions and clinical diseases
In recent years, the circadian clock has attracted much attention from the medical community. Last year’s Nobel Prize in Medicine was awarded to scholars in this field. Human sleep cycles and circadian rhythms are closely related to each other and are independent of each other. If the body's biological clock is disrupted, it will lead to many physiological conditions and clinical diseases, such as stroke, asthma, sleep disorders, etc. Dr. Ming's research is an important discovery in chronobiology. In the future, he will further try to establish a circadian clock model from brain science, and move towards the goal of regulating the circadian clock and promoting human health and well-being. Join and pay attention to your health every day! LINE＠ ID: @ Subscribe to the Healthy Love Live video and audio channel and read health knowledge more easily: /supply/article/38244 Keywords: Shuanghe Hospital, Brain and Consciousness Research Center, Mingzhihuan, choroid plexus, cerebrospinal fluid, embryo< /p>