1, non-steroidal anti-inflammatory drugs: with analgesic and anti-inflammatory effects, it is a commonly used drug to relieve the symptoms of arthritis. Commonly used drugs include ibuprofen, diclofenac, indomethacin and so on. Major adverse effects include gastrointestinal, hepatic and renal impairment, as well as a possible increase in cardiovascular adverse events. Concomitant administration of two or more NSAIDs should be avoided. Topical preparations of NSAIDs such as ketoprofen gel and piroxicam patches are useful in relieving joint swelling and pain, with fewer adverse effects.

2, traditional anti-rheumatic drugs: can delay and control the progress of the disease. Commonly used drugs include methotrexate, leflunomide, hydroxychloroquine, azathioprine, cyclosporine and so on. The main adverse effects of leflunomide include gastrointestinal reactions, liver damage, alopecia, bone marrow suppression and hypertension, etc. It has teratogenic effects and is contraindicated in pregnant women. Cyclosporine prominent adverse reactions are blood creatinine and blood pressure rise, it is advisable to closely monitor during the drug.

3, biological anti-rheumatic drugs: is currently active and effective control of inflammation is an important drug, can reduce bone destruction, reduce hormone dosage and osteoporosis. Currently the most commonly used are tumor necrosis factor-α antagonist, interleukin-6 antagonist. Commonly used drugs for tumor necrosis factor-alpha antagonists include etanercept, infliximab, and golimumab. The main side effects of these drugs include injection-site reactions and infusion reactions, which may increase the risk of infections, especially tuberculosis infections, and some biologics increase the potential risk of developing tumors with long-term use. Screening for tuberculosis should be performed prior to drug administration to exclude active infection and tumors. Common adverse reactions to interleukin-6 antagonists are infections, gastrointestinal symptoms, rash, and headache.