Scrotal eczema is related to allergies just like eczema in other parts, so all drugs used to treat allergies can be used to treat scrotal eczema. For example, some commonly used antihistamines, such as cyproheptadine 2mg, three times a day; Chlorpheniramine 4mg, 3 times a day; Keminzine 25mg, three times a day; Sismin 10mg, once a day 1 time. Topical drugs are mainly corticosteroid ointment, such as triamcinolone acetonide ointment, Fule ointment and Youdrol ointment.

Traditional Chinese medicine treatment is mainly based on syndrome differentiation. Traditional Chinese medicine often divides scrotal eczema into two types: damp-heat downward flow syndrome and yin deficiency and blood dryness syndrome. Damp-heat downward flow syndrome is equivalent to acute scrotal eczema, and yin deficiency and blood dryness syndrome is equivalent to chronic scrotal eczema.