Chronic myeloid leukemia (CML) is more common in adults aged 30 ~ 40, with more males than females. The patient has emaciation, weakness, fever, night sweats, pallor, dizziness, palpitation, sternal tenderness, joint pain, hepatosplenomegaly and late anemia.
I. acute myeloid leukemia
Symptoms and signs
(1) Fever: Fever is mostly caused by infection.
(2) Bleeding: There may be skin and mucous membrane bleeding in the early stage; Then visceral bleeding or disseminated intravascular coagulation.
(3) Anemia: progressive aggravation.
(4) Leukemia cell infiltration: lymph nodes, hepatosplenomegaly and sternal tenderness. It can also be manifested as infiltration of other parts, such as pleural effusion, peritoneal effusion or pericardial effusion, and infiltration of the central nervous system.
Second, acute lymphoblastic leukemia
Symptoms and signs
(1) Fever: Fever is mostly caused by infection.
(2) Bleeding: There may be skin and mucous membrane bleeding in the early stage; Then visceral bleeding or disseminated intravascular coagulation.
(3) Anemia: progressive aggravation.
(4) Proliferation and infiltration of leukemia cells:
1) Hepatosplenic lymphadenopathy: T cell ALL is often accompanied by mediastinal lymphadenopathy.
2) Bone and joint pain: sternal tenderness is one of the common symptoms.
3) Nervous system leukemia: It mostly occurs in remission stage of leukemia, and the incidence of ALL is higher than that of AML.
4) Testis: mostly unilateral painless testicular swelling.