Siwu Decoction Prescription

What is Siwu Decoction? Siwu Decoction has the effect of nourishing blood and regulating menstruation, and can also relieve women’s dysmenorrhea. So do you know what the prescriptions of Siwu Decoction are? What are the pharmacological effects of Siwu Decoction? Let me introduce the relevant content to you below.

Siwu Soup

Siwu Soup is a traditional medicinal meal. It is made from the four medicinal herbs of angelica, chuanxiong, white peony root and rehmannia glutinosa as the main raw materials. It is a classic medicinal diet used in traditional Chinese medicine to nourish and nourish blood.

The prescription of Siwu Decoction was first recorded in the "Secret Prescriptions for Dipsacus Dipsacus Recipe" written by Taoist Lin of the Tang Dynasty. The most widely used prescription at present is taken from the "Prescription of Taiping Huimin Mixture" records. Generally speaking, it has the effect of nourishing blood and regulating menstruation, which can relieve women's menstrual pain.

Siwu Decoction Prescription

This prescription consists of four herbs: Angelica sinensis, Chuanxiong rhizome, white peony root and rehmannia glutinosa. It is used for symptoms such as dizziness, dizziness, tinnitus, dull lips and claws, scanty menstruation or amenorrhea in women, pain in the navel and abdomen, pale tongue, stringy or stringy pulse, etc. It has the effect of nourishing blood and regulating menstruation.

Pharmacological effects

Mainly include correction of anemia, anti-radiation damage, anti-platelet aggregation, anti-thrombosis, anti-hypoxia, anti-free radical damage, inhibition of granulation proliferation, inhibition of uterine activity, Regulate immune function, supplement trace elements, phospholipids, vitamins, etc.

1. Correct anemia: Intraperitoneal injection of methylcellulose (MC) into rats or mice can cause experimental anemia; splenomegaly and renal lesions may occur, and the animal mortality rate is high. Our n-butanol extract can reduce the mortality of the model mice, and hematological observations also show that it has an anti-anemia effect, but it has no effect on the model rats. The aqueous extract of this drug has only a slight inhibitory effect on hemorrhagic anemia caused by phenylhydrazine. For acute blood loss anemia caused by bloodletting in mice, after oral administration of this drug, it was found that the bone marrow image examination of the ratio of granulocytes to red blood cells, the percentage of nucleated cells, and the morphology and quantity of bone marrow staining could improve the hematopoietic function of the bone marrow and promote For the recovery of anemia, the simple Qi-tonifying prescription Sijunzi Decoction is less effective than this prescription. It also has a certain therapeutic effect on rats with hemolytic anemia, but the effect is weaker than Sijunzi Decoction. This prescription increases the red blood cells, hemoglobin, reticulocytes and other formed blood components in animals with experimental acute hemorrhagic anemia to varying degrees, with hemoglobin increasing significantly.

2. Anti-radiation damage: Before irradiating normal mice with lethal doses of radiation, intraperitoneal injection of 200mg/kg Siwutang methanol extract can achieve better protective effects. However, this prescription has no such effect when given after radiation exposure. This protective effect is dependent on Chuanxiong, and angelica and peony have auxiliary effects.

3. Anti-platelet aggregation and anti-thrombosis: Siwu Decoction has a significant inhibitory effect on ADP-induced platelet aggregation in rabbits. This effect is achieved by increasing the AMP concentration and ferulic acid in platelets. content to achieve. In the anti-external thrombus experiment, it was observed that no thrombus appeared in the Siwu Decoction group, while the thrombus length (mm), wet weight (mg), and dry weight (mg) of the control group were 0.2±0.61, 77.8±14.51, and 35.7±4.69 respectively. .

4. Anti-hypoxia: mice are generally hypoxic under normal pressure, isoproterenol causes myocardial hypoxia, common carotid artery ligation causes cerebral hypoxia, and sodium nitrite poisoning causes cellular hypoxia. In the experiment, the survival times (minutes) of the Siwu Decoction group (intraperitoneal injection of 0.1ml/10g body weight of the hydroalcoholic extract of Siwu Decoction) were 7.57±1.68, 6.22±0.74, 4.67±1.35, and 52.5±4.1, respectively. The survival times (minutes) of the control group (intraperitoneal injection of equal volume of normal saline) were 5.71±0.43, 5.19±0.84, 2.82±1.10, and 25.8±7.4 respectively. It has been proved that Siwu Decoction has good anti-hypoxia effect.

5. Anti-free radical damage: After receiving O3 stimulation, young rats can develop symptoms similar to the decline of physiological functions of older animals, such as physical strength, cold resistance and hypoxia tolerance. Wutang has a significant improvement effect on the above-mentioned indicators in the aging model.

The activity of MAO-B in the brains of mice in the experimental model group increased, showing biochemical changes consistent with those of aged animals. The chemiluminescence inhibition rate of the serum of mice in the administration group increased, and the SOD activity increased; the lipid peroxide content in plasma, brain, and liver tissue and the MAO-B activity of brain tissue decreased; there was a dose-effect relationship between different doses.

6. Inhibit granulation proliferation: Make adjuvant granulation cysts on the backs of ddy mice, and administer SiWuchang (50-200mg/kg) intraperitoneally. It can be seen that the wet weight of granulations and the amount of new blood vessels are both the same. It can be inhibited in a dose-dependent manner, with a maximum inhibition rate of 40. In the inhibitory effect of Siwu Decoction on granuloma proliferation, Ligusticum Chuanxiong and Angelica sinensis, which constitute the crude drug, play a major role. Its mechanism of action is by inhibiting the proliferation of vascular smooth muscle cells. The promotion effect of 10 calf serum on the proliferation of cultured vascular smooth muscle cells was dose-dependently inhibited by Siwu Decoction (4-500 μg/ml), with a maximum inhibition rate of 46.

7. Inhibit uterine muscle activity: Taking Angelicae Sinensis, White Peony Root, Ligusticum Chuanxiong, Lycium barbarum, Cyperus rotunda and Licorice as the basic formula, and its concentration is 1×10-2 (g/ml), the effect on rats is The spontaneous movement of the uterus has an inhibitory effect, the frequency is significantly reduced, and the muscle tone decreases slightly. The average inhibition rate of the frequency in the 5 minutes before and after administration is 53.3. When 2.5ml/kg (5g/kg) of this prescription is administered into the duodenum, it has a significant inhibitory effect on the frequency of spontaneous uterine movement in rabbits. 60-70 minutes after administration, the average frequency inhibition rate was 42, and the change in muscle tone was not obvious. However, this prescription has no effect on the contraction amplitude of spontaneous movement of rat uterus in vitro and rabbit uterus in vivo. When the concentration of this prescription is 1×10-2 (g/ml), it can weaken the uterine contraction response caused by prostaglandin F2α concentration of 2.5×10-7 (g/ml), with a slight increase in muscle tension and a decrease in frequency.

8. Regulate immune function: Through lymphocyte transformation test and active spot test, it is shown that this prescription has a significant promoting effect on cellular immune response. When 2 μg/ml HC and 2 mg/ml Siwutang were added to 4×10-7/ml splenocyte suspension, the OD values ??were 0.326±0.037 and 0.696±0.159 respectively, indicating that this prescription can counteract the effects of HC on lymphocyte proliferation. Inhibitory effects; in terms of delayed-type skin hypersensitivity (DCH) against CY inhibition in mice, hemolysin production in sheep red blood cells (SRBC) sensitized mice against CY inhibition, and charcoal particle clearance rate in mice against CY inhibition, etc. All have certain effects.

9. Supplement trace elements: The flame atomic absorption method was used to measure Cu, Zn, Mn, and Fe. The graphite furnace atomic absorption method was used to measure Ni, Cd, Po, and Cr. Most of these trace elements are related to blood production.

10. Supplement phospholipids and vitamins: The total phospholipid content in Siwu Decoction is 0.025 mg/g using molybdenum blue colorimetry, and the vitamin C content in this recipe is 61.20 mg/g using high performance liquid chromatography. , folic acid 0.212mg/g.

The above is the content of the Siwu Decoction prescription introduced to you. After reading this, you will know what Siwu Decoction is. Siwu Decoction has the effect of nourishing blood and regulating menstruation.