As the saying goes, people who eat whole grains are not sick. If they are sick, they will naturally take medicine. When taking medicine, doctors often tell us to pay attention to taboos, such as spicy and irritating food, which is best not to eat. However, there is a kind of fruit, which is also taboo by many doctors. You can't eat it during taking the medicine, and it is even life-threatening when it is serious. Do you dare to ignore it?

Grapefruit is a kind of grapefruit fruit with red flesh, sweet and sour taste, also known as grapefruit. Rich in vitamin C, folic acid and dietary fiber, and low in sugar content, it is deeply loved by women and sought after by dieters. Although it is good to travel to the west, there is a substance in grapefruit that doctors are forbidden to take medicine. Its coumarin component can interact with some drugs and even cause serious side effects, which are life-threatening.

The richness of material life is followed by the high incidence of various chronic metabolic diseases such as hypertension and hyperlipidemia. For some antihypertensive drugs, lipid-lowering drugs and other drugs, grapefruit juice can not be taken, and the interval between eating grapefruit and taking medicine is at least 12 hours. Studies have shown that flavonoids and furocoumarins contained in grapefruit can make drugs enter the blood several times or even dozens of times than usual, thus improving the absorption level of drugs and improving the curative effect of drugs; At the same time, the components in grapefruit can inhibit the organic anion transport polypeptide located on human small intestinal epithelial cells, thus inhibiting the bioavailability of the drug; It can also inhibit the outward transport carrier protein P- glycoprotein located on human small intestinal epithelial cells and improve the bioavailability of the drug. Nifedipine tablets are antihypertensive drugs often taken by hypertensive patients, which will lower blood pressure after taking antihypertensive drugs. If you eat grapefruit after taking the medicine, the efficacy of antihypertensive drugs may increase several times, and blood pressure will drop rapidly, thus causing hypotension. For patients with hypertension, the level of blood pressure may cause more health risks, even life-threatening.

In fact, grapefruit should be avoided not only for hypertensive patients taking nifedipine tablets, but also for some statins such as simvastatin tablets, atorvastatin calcium tablets, cerebrovascular drugs such as nimodipine tablets and antiarrhythmic drugs such as amiodarone hydrochloride tablets. The time to eat grapefruit should be separated from the time to take it 12 hours, and the physical condition should be monitored to prevent accidents.

During taking medicine, you should not only follow the doctor's advice, but also read the drug instructions carefully. At present, 85 drugs have been found to react with grapefruit, of which 43 drugs can cause serious side effects. The United States has required that the instructions of some prescription drugs must indicate that the drug is forbidden to be taken with grapefruit juice or fresh grapefruit. In some commonly used oral drug instructions, it is clearly indicated that there is an interaction with grapefruit.