Vitamin E is usually non-toxic. When taken in high doses (more than 1,200 international units per day), it can cause adverse reactions such as regurgitation, gas and bloating, diarrhea, and rapid heartbeat. Consult your health advisor before taking vitamin E if you have: If you have high blood pressure. If you are using an anticoagulant such as sodium acetone coumarin or acetone benzylhydroxycoumarin If vitamin E is taken at the same time as acetone benzylhydroxycoumarin, a blood-clotting agent, it can increase the likelihood of paradoxical bleeding. A type of cholesterol-lowering medication called bile acid sequestrants (such as colestipol and cholestyramine) reduces vitamin E absorption. Vitamin E interacts with cyclosporine (a drug used to treat cancer), reducing the effectiveness of both. Overdose Is vitamin E really beneficial in large doses? Robert, an American medical expert, advises that taking large doses of vitamin E over a long period of time can cause a variety of diseases. Among the more serious are: thrombophlebitis or pulmonary embolism, or both occur at the same time, this is due to large doses of vitamin E can cause platelet aggregation and formation; elevated blood pressure, stopping the drug blood pressure can be lowered or return to normal; both sexes can be breast enlargement; headache, dizziness, vertigo, blurred vision, muscle weakness; skin cracking, labial inflammation, xerostomia, urticaria; diabetes mellitus or angina symptoms are obvious Aggravation; hormone metabolism disorders, reduced thromboplastin; blood cholesterol and triglyceride levels increased; platelet increase and increased vitality and immune function is reduced. Vitamin E toxicity Adults taking relatively large doses of vitamin E (dextro-alpha-tocopherol 400-800mg/d) for years without any significant damage. Occasional muscle weakness, fatigue, vomiting, and diarrhea may occur with doses of 800-3200 mg/d. The most pronounced toxic effect of vitamin E >1000 mg/d is antagonism of vitamin K and potentiation of the effects of oral coumarin anticoagulants, which can lead to significant bleeding.