1, studies have shown that nattokinase may help reduce creatinine levels. It was found that the creatinine level of patients taking nattokinase was lower than that of patients taking placebo. The risk of renal function deterioration in patients taking nattokinase is reduced.

2. Nattokinase is a natural enzyme found in natto. It is considered to have anticoagulant and thrombolytic effects. Creatinine is a waste produced by muscle metabolism. It is excreted by the kidneys. Elevated creatinine level may indicate renal insufficiency.