Contents 1 Pinyin 2 English reference 3 National Essential Medicines 4 Overview 5 Source 6 Origin 7 Meridian distribution of nature and taste 8 Efficacy and indications 9 Usage and dosage of Qianghuo 10 Chemical composition 11 Pharmacological effects of Qianghuo 12 Pharmacopoeia standards of Qianghuo 12.1 Product Name 12.2 Source 12.3 Properties 12.3.1 Wide Leaf Live 12.4 Identification 12.5 Examination 12.5.1 Total ash 12.5.2 Elertwriter Gray Division 12.7 Email 12.7 Conduct 12.7.1 Volatile Oil 12.7.2 Live Alcohol and Different Hou Hu Su Live Decoction pieces 12.8.1 Processing 12.8.2 Identification, inspection, extract and content determination 12.8.3 Nature, flavor and meridians 12.8.4 Functions and indications 12.8.5 Usage and dosage 12.8.6 Storage 12.9 Source 13 References attached: 1 Use Prescriptions for the traditional Chinese medicine Qianghuo 2 Chinese patent medicines using the traditional Chinese medicine Qianghuo 3 Notopterygium incisium in ancient books* Qianghuo drug instructions 1 Pinyin

qiāng huó 2 English reference

Notopterygium incisium [Landao Chinese-English] Dictionary]

rhizoma et radix notopterygii [Landau Chinese-English Dictionary]

incised notopterygium rhizome or root [Xiangya Medical Professional Dictionary]

notopterygii,rhizoma [ Xiangya Medical Professional Dictionary]

Rhizoma et Radix Notopterygii (LA) [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]

incised notopterygium rhizome and root [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 National Essential Drugs

National Essential Drugs Retail Guidance Price Information Serial Number Essential Drugs Related to Qianghuo

Table of Contents Serial No. Drug Name Dosage Form Specifications Unit Retail Instructions

Price Guide Remarks 1 1 Jiuwei Qianghuo Pills Honey Pills 9g Pills 0.58 Part of Chinese Patent Medicines* 2 1 Jiuwei Qianghuo Pills Concentrated Pills 3g Bag 0.27 Part of Chinese Patent Medicines 3 1 Jiuwei Qianghuo Pills Concentrated Pills 4.5g Bag 0.41 Chinese Patent Medicine Part 4 1 Jiuwei Qianghuo Pills Concentrated Pills 9g Bag 0.81 Chinese Patent Medicine Part 5 1 Jiuwei Qianghuo Pills Water Pills 6g Bag 0.6 Chinese Patent Medicine Part*△ 6 1 Jiuwei Qianghuo Pills Water Pills 2.5 g bag 0.27 Chinese patent medicine part 7 1 Jiuwei Qianghuo pills water pills 4.5g bag 0.46 Chinese patent medicine part 8 1 Jiuwei Qianghuo pills water pills 9g bag 0.87 Chinese patent medicine part 9 1 Jiuwei Qianghuo pills water pills 18g bag 1.7 Chinese patent medicine part 10 1 Jiuwei Qianghuo pills water pills Qianghuo Pills Water Pills 30g Bottle 2.7 Chinese Patent Medicine Part 11 1 Jiuwei Qianghuo Pills Water Pills 60g Bottle 5.1 Chinese Patent Medicine Part 12 1 Jiuwei Qianghuo Granules 15g Bag 1.3 Chinese Patent Medicine Part* 13 1 Jiuwei Qianghuo Granules 5g (sugar-free) Bag 1.4 Part of Chinese Patent Medicine

Note:

1. The dosage forms and specifications marked with “*” in the remarks column in the table are representative products.

2. The dosage form specifications marked with “△” in the remarks column of the table and other specifications of the same dosage form are provisional prices.

3. The dosage form specification indicates the usage and dosage in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage and are calculated according to the "Drug Price Difference Rules".

4. The "Mi Wan" marked in the dosage form column in the table includes Xiao Mi Wan and Dami Wan. 4 Overview

Qianghuo is the name of a traditional Chinese medicine, published in "Shen Nong's Materia Medica". It is the dried rhizome and root of Notopterygium incisum Ting ex H. T. Chang or Notopterygium forbesii Boiss. [1].

"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeia standards of this traditional Chinese medicine. 5 Sources

Notopterygium incisum Ting ex H.T.Chang or Notopterygium incisum N. rhizomes and roots of forbesii Boiss.[2].

Notopterygium incisum Ting ex H. T. Chang or Notopterygium forbesii Boiss. is the dried rhizome and root of Notopterygium incisum Ting ex H. T. Chang [1]. 6 Origin

Qianghuo is mainly produced in Sichuan, Gansu and Qinghai [2]. 7. Meridian distribution of nature and flavor

Qianghuo tastes pungent and bitter, and is warm in nature; it enters the bladder and kidney meridians [2]. 8 Efficacy and Indications

Qianghuo has the effects of dispelling wind and relieving the surface, dehumidifying and relieving pain:

Treats colds, wind and cold, aversion to cold and fever, headache, body pain, rheumatic paralysis, tetanus[ 2].

Treat carbuncle, furuncle, urticaria, and skin itching[2].

Qianghuo is a commonly used medicine for dispelling wind and cold in ophthalmology. It has the effects of relieving superficial cold, dispelling wind and stopping tears, and relieving dampness and relieving pain:

(1) Used for exogenous wind and cold. Cold tears in the wind. It is often combined with Fangfeng and Ligusticum chuanxiong, such as mixing it with Ligusticum chuanxiong tea. It can also be used for frequent cold discharge caused by insufficient liver blood. It is often combined with Angelica sinensis and Chuanxiong rhizome, such as Tongcao powder.

(2) It is used for aversion to cold, fever, headache, body aches, shoulder and back pain caused by external wind-cold or dampness evil.

(3) It is used to induce the meridians to ascend the head, and is used with raw and cooked rehmannia glutinosa, angelica root, etc. to treat tightness and astringency of the eyes due to lack of essence and blood.

(4) It is used to raise Yang and improve eyesight. It is often used with Cimicifuga, Bupleurum, Fangfeng, etc., along with tonic agents, to treat dim vision caused by spleen deficiency and weak Qi and lack of clear Yang. Can't look for a long time, pain when looking for a long time, etc. 9 Usage and dosage of Qianghuo

Decoction: 3~9g[2]. 10 Chemical composition

Asparagus contains volatile oils, including pinene, β-ocimene, α-tuberene, Apiol, Guaiol, etc. It also contains Cdumbiain, psyllium lactone, etc. [2]. 11 Pharmacological effects

Qianghuo has an inhibitory effect on Brucella in vitro [2]. And it can antagonize animal epilepsy caused by electroacupuncture [2]. 12 Pharmacopoeia standards for Qianghuo 12.1 Product name

Qianghuo

Qianghuo

NOTOPTERYGII RHIZOMA ET RADIX 12.2 Source

This product is a plant from the Umbelliferae family Notopterygium incisum Ting ex H.T. Dried rhizomes and roots of Chang or Notopterygium, francetii H. de Boiss. Excavate in spring and autumn, remove fibrous roots and sediment, and dry in the sun. 12.3 Characteristics

Qianghuo is a cylindrical, slightly curved rhizome, 4 to 13 cm long, 0.6 to 2.5 cm in diameter, with a stem scar at the top. The surface is tan to dark brown, and the areas where the outer skin peels off are yellow.

The internode is shortened and is in the shape of a tight raised ring, resembling a silkworm, and is commonly called "silkworm Qiang"; the internode is extended and is shaped like a bamboo joint, commonly known as "bamboo knot Qiang". There are many punctate or knob-like protruding root marks and brown broken scales on the nodes. The body is light, brittle, easy to break, the cross-section is uneven, and there are many cracks. The skin is yellow-brown to dark brown, oily, with brown oil spots, the wood is yellow-white, with obvious rays, and the pith is yellow to yellow-brown. The smell is fragrant and the taste is slightly bitter and pungent. 12.3.1 Rhizoma latifolia

consists of rhizomes and roots. The rhizome is cylindrical, with stem and leaf sheath residues at the top, and the root is conical, with longitudinal wrinkles and lenticels; the surface is tan, with dense ring patterns near the rhizome, and is 8 to 15 cm long. With a diameter of 1 to 3cm, it is commonly called "Tiao Qiang". Some rhizomes are thick, irregular and nodular, with several stem bases on the top and thin roots. They are commonly called "Datou Qiang". The texture is crispy, easy to break, the cross-section is slightly flat, the skin is light brown, and the wood is yellow-white. The smell is lighter. 12.4 Identification

Take 1g of this product powder, add 5ml of methanol, ultrasonicate for 20 minutes, let it stand, and take the supernatant as the test solution. In addition, take the purpuroside reference substance, add methanol to make a solution containing 0.5mg per 1ml, and use it as the reference solution. According to the thin layer chromatography (Appendix VIB) test, absorb 2 to 4 ul of each of the above two solutions, and place them on the same silica gel G thin layer plate prepared with 3% sodium acetate solution. Use chloroform-methanol (8:2 ) is the developing agent, unfold, take out, dry, and inspect under ultraviolet light (365nm). In the chromatogram of the test product, the same blue fluorescent spot appears at the position corresponding to the chromatogram of the reference substance. 12.5 Inspection 12.5.1 Total ash content

shall not exceed 8.0% (Appendix IX K). 12.5.2 Acid-insoluble ash

shall not exceed 3.0% (Appendix IX K). 12.6 Leachables

Determine according to the hot soak method under the alcohol-soluble leachables determination method (Appendix XA), using ethanol as the solvent, not less than 15.0%. 12.7 Content determination 12.7.1 Volatile oil photo

Determination of volatile oil determination method (Appendix X D).

This product contains volatile oil not less than 1.4% (ml/g). 12.7.2 Enchantol and isopretinol

Determination according to high performance liquid chromatography (Appendix VID).

Chromatographic conditions and system suitability test: Use octadecylsilane bonded silica gel as the filler; use acetonitrile-water (44:56) as the mobile phase; the detection wavelength is 310nm. The number of theoretical plates should not be less than 5,000 based on the ethanol peak.

Preparation of the reference solution: Take an appropriate amount of the fentanyl alcohol reference substance and the isoimperatorin reference substance, weigh them accurately, and add methanol to make a mixture containing 60 μg of the fentanyl alcohol and 30 μg of the isoimperatorin per 1 ml. Solution is obtained.

Preparation of test solution: Take about 0.4g of this product powder (passed through No. 3 sieve), weigh it accurately, place it in a stoppered conical flask, add 50ml of methanol accurately, weigh it, and treat it with ultrasonic (Power 250W, frequency 50kHz) for 30 minutes, let cool, weigh again, use methanol to make up for the lost weight, shake well, filter, and take the remaining filtrate to get it.

Determination method: Precisely draw 5 μl of the reference solution and 5 to 10 μl of the test solution, inject them into the liquid chromatograph, and measure.

This product shall contain no less than 0.40% of the total content of coquinol (C21H22O5) and isoimperatorin (C16H14O4) as a dry product. 12.8 Qianghuo decoction pieces 12.8.1 Processing

Remove impurities, wash, moisten, cut into thick slices, and dry in the sun.

This product is round or irregular in cross-cut or diagonal slices. The epidermis is brown to dark brown, the outside of the cut surface is brown, the wood is yellow-white, and some have radial textures. Light in body and brittle in texture. The smell is fragrant and the taste is slightly bitter and pungent. 12.8.2 Identification, inspection, extractables and content determination

Same as medicinal materials. 12.8.3 Nature, flavor and meridians

Pungent, bitter and warm. Returns to the bladder and kidney meridians. 12.8.4 Functions and indications

Relieves surface and dissipates cold, expels wind and dampness, and relieves pain. It is used for colds, headaches, nape pain, rheumatic arthralgia, shoulder and back pain.

12.8.5 Usage and dosage

3～10g. 12.8.6 Storage

Store in a cool, dry place to prevent moth. 12.9 Source

"The Pharmacopoeia of the People's Republic of China" 2010 Edition 13