With the aggravation of anemia, patients will gradually develop many systemic symptoms, such as:
(1) cardiovascular system: heartbeat accelerates after activity, conscious panic, shortness of breath, angina and heart failure can occur in severe anemia.
(2) Neurological symptoms: headache, tinnitus, blurred vision, poor concentration, insomnia, drowsiness and fear of cold. Fainting or blurred consciousness can occur in severe anemia. Vitamin Bl2 deficiency is often accompanied by numbness of the limbs, sensory withdrawal.
(3) Digestive symptoms: loss of appetite, bloating, nausea.
(4) Genitourinary symptoms: polyuria, decreased urine specific gravity, some patients may have a small amount of protein in the urine, and menstrual disorders in female patients.
The main signs of anemia are: pale skin, often with pale face, palms, lips and mouth. Pallor of the nail beds, conjunctiva and tongue is more pronounced. Other signs can be dry and inelastic skin, hair without luster.