Niu Huang Detoxification Tablets are over-the-counter medicines that are easily available to the public, and many small family medicine boxes are stocked with this medicine. It is made of artificial oxalis, andrographis, gypsum, rhubarb, scutellaria, platycodon, icicle and licorice, which can clear the fire of the triple jiao, clear the lungs and stomach of the real heat, and remove stagnation, and it is mostly used in the treatment of mouth sores, toothache, tonsillitis, pharyngitis and constipation, and other common ailments. It should be noted that the andrographis in Niu Huang Antidote Tablets contains arsenic, which belongs to heavy metal minerals, and can damage the liver, kidneys, blood system, nervous system and reproductive system, and can accumulate in the body. The Pharmacopoeia of the People's Republic of China (P.R.C.) stipulates that the arsenic content in medicines is at the level of one billionth of a gram, and some experts have recently suggested that its safety should be evaluated. In recent years, it has been found that the adverse reactions caused by taking oxalic detoxification tablets involve the nervous, circulatory, urinary, respiratory, digestive, blood and other systems, presenting a variety of symptoms such as skin rashes, anaphylactic shock, liver damage and arsenic poisoning. Arsenic can act on proteins and cause allergic lesions, and common allergic reactions are skin papule-like plaques, itching, and in severe cases, exfoliative dermatitis and anaphylaxis. The digestive system reaction caused by oxalic detoxification tablets, symptoms manifested as epigastric fullness and discomfort, pain, as well as nausea, vomiting and blood in the stool, gastroscopy can be seen in gastric mucosal congestion, edema, with vesicles and hemorrhagic spots. Urologic reactions may include lumbar pain, symptoms of urinary frequency and urgency, as well as hemorrhagic cystitis and hematuria. The neurologic adverse reactions it causes are commonly characterized by drowsiness, confusion, twitching of the limbs, and sedentary reticence. Respiratory reactions may manifest as bronchial asthma-like reactions with symptoms such as cough, palpitation, chest tightness, cyanosis of lips and mouth, dyspnea, and inability to lie down. Oxalic acid detoxification tablets may cause acute jaundice and other symptoms of hepatic impairment. Hematological reactions are mainly thrombocytopenia and simple red blood cell aplastic anemia, with clinical manifestations such as oral mucosal ulcers, bleeding gums and bleeding spots on the skin. In addition, niu huang detoxification tablets can cause a certain medication addiction effect. Certain patients prefer to use Niu Huang Xie Tu Wei Tablet. Some literature believes that the long-term use of the drug can cause addiction, after stopping the drug occurs similar to the withdrawal symptoms like reaction, resulting in increased swelling and pain in the throat, general malaise, excitement, insomnia, decreased appetite, constipation symptoms, and then take the drug after the above symptoms can be relieved. Therefore, the drug should be taken with caution, and do not arbitrarily increase the dose.