① Effects on cardiovascular system: The extracts, tinctures and decoctions of Cortex Lycii have obvious hypotensive effects on intravenous injection in anesthetized dogs, cats and rabbits, accompanied by slow heart rate and accelerated breathing; The effect of immersion seems to be better than that of decoction; Repeated administration can produce rapid tolerance in different degrees. Concentrated tincture given to anesthetized dogs and cats by intramuscular injection or decoction given to anesthetized rats by gavage also showed a lasting and stable antihypertensive effect. The hypotensive effect of cortex Lycii is related to the center, and it may also block sympathetic nerve endings and directly relax blood vessels. During the period of blood pressure reduction, there was no obvious change in ECG except the slow heart rate and the decrease of T wave. The toxic dose could cause partial or even complete atrioventricular conduction block in guinea pigs' hearts. ② Hypoglycemic effect: After oral administration of Lycium barbarum decoction to rabbits, the blood sugar first increased for a short time, then decreased for a long time, and it has not recovered after 4-8 hours. There is no obvious antagonistic effect on hyperglycemia caused by adrenaline injection. The blood sugar is also reduced by subcutaneous injection of the extract in rabbits. Another bearded extract of Lycium barbarum root can significantly and permanently reduce the blood sugar in rats and increase the carbohydrate tolerance. Its hypoglycemic effect is due to its guanidine derivatives. ③ Antipyretic effect Cortex Lycii has obvious antipyretic effect on rabbits with artificial fever. The ether extract and the water extract of the residue after ethanol extraction have no effect, but the ethanol extract, the water extract or the water extract of the residue after ether extraction have effect. Its antipyretic effect is weaker than that of aminopyrine, which is about equal to other antipyretics.