Analysis of illness: Syphilis is a chronic systemic venereal disease caused by Treponema pallidum infection. It is mainly transmitted through sexual intercourse. The manifestations of the disease are extremely complex, which can invade almost all organs of the whole body and cause multiple organ damage. Such as an ulcer or chancre at the infected site of primary syphilis; Secondary syphilis skin and mucous membrane damage, lymph node enlargement; The heart, nerves, stomach, eyes and ears of tertiary syphilis are all involved, and the gums are swollen and damaged. Suggestion: Yes, the symptoms after the development of secondary syphilis are: 1. Skin and mucous membrane damage; 2. Systemic lymphadenopathy; 3. Bone and joint injuries; 4. verruca plana; 5. hair loss; 6. Rash.