2 English reference Da Dingfeng Zhu [2 1 century bilingual dictionary of science and technology]
Large WindExpelling Decoction [Xiangya medical dictionary]
Dadingfengzhu pill [Terminology Committee of Traditional Chinese Medicine. Terminology of Traditional Chinese Medicine (2004)]
3 Overview The wind beads in Dading are recorded in Volume III of Treatise on Epidemic Febrile Diseases, and they are composed of two gallus gallus domesticus brisson, donkey-hide gelatin 9g, raw white peony root 18g, raw tortoise plastron 12g, dried rehmannia root 18g, hemp seed 6g, Schisandra chinensis 6g, raw oyster 12g and Ophiopogon japonicus/kloc. Indications are yin deficiency and wind-moving syndrome. This prescription is a commonly used representative prescription for the treatment of yin deficiency and wind-moving syndrome in the late stage of epidemic febrile disease. Modern medicine is often used to treat convulsion, zinc deficiency, acute renal failure and tongue atrophy after radiotherapy in the late stage of febrile diseases such as Japanese encephalitis. [ 1]
Dading Fengzhu is the name of the prescription, which comes from Volume II of Treatise on Warm Diseases [2].
This prescription has a certain therapeutic effect on "weak pulse and qi, which is always wanting to get rid of" in the late stage of epidemic febrile disease by regulating nervous, endocrine, metabolic, immune and cardiovascular functions. From the perspective of modern medicine, it should have a certain therapeutic effect on various severe infectious diseases complicated with brain dysfunction, heart and circulatory dysfunction, especially dehydration and electrolyte disorder, and various shocks. However, all kinds of febrile diseases are serious in the later stage, so it is necessary to combine modern medical methods, especially cardiotonic, anti-shock, correcting dehydration acidosis, correcting electrolyte disorder and supplementing heat. This prescription should also be combined with effective antibiotics and antiviral drugs. [3]
4 gallus gallus domesticus brisson 2, Colla Corii Asini 9g, Radix Paeoniae Alba 18g, Carapax et Plastrum Testudinis 12g, Radix Rehmanniae 18g, Fructus Cannabis 6g, Fructus Schisandrae 6g, Oyster 12g, Radix Ophiopogonis 18g, and Carapax Trionycis/kloc-0.
Radix Paeoniae Alba 18g, Colla Corii Asini 9g, Plastrum Testudinis 12g, Radix Rehmanniae 18g, Fructus Cannabis 6g, Fructus Schisandrae 6g, Concha Ostreae 12g, Radix Ophiopogonis (Lianxin) 18g, and Radix Glycyrrhizae Preparata 12g.
White peony, dried rehmannia root and Ophiopogon japonicus (Lianxin) each cost six yuan, donkey-hide gelatin San Qian, raw tortoise shell, raw oyster shell, roasted licorice root and raw turtle shell each cost four yuan, hemp seed and Schisandra chinensis each cost two yuan, and two raw gallus gallus domesticus brisson [2].
Six dollars for raw white peony root, four dollars for raw donkey-hide gelatin San Qian, four dollars for raw tortoise plastron, six dollars for dried rehmannia root, two dollars for hemp seed, two dollars for Schisandra fruit, four dollars for raw oyster, six dollars for Ophiopogon japonicus (Lianxin), four dollars for roasted licorice, two dollars for gallus gallus domesticus brisson (raw) and four dollars for turtle shell (raw) [5].
Usage: Take eight cups of water, boil three cups, remove me, melt the donkey-hide gelatin, and then go back to gallus gallus domesticus brisson, stir and get it, and take it three times. [ 1]
Decoct with water to remove residue, and then enter gallus gallus domesticus brisson, where it is mixed and taken in three times [2].
Decoct that above materials in wat, removing impurities, adding colla Corii Asini, mel, mixing, and taking in gallus gallus domesticus brisson for 3 times, daily 1 dose. [4]
Eight cups of water, three cups of boiled water, go to me, re-enter gallus gallus domesticus brisson, and mix them up and take them three times [5].
6. Dading Fengzhu, which is mainly used to treat the three aspects of Treatise on Epidemic Febrile Diseases, has the effect of nourishing yin and calming wind, nourishing yin and nourishing fluid, and softening the liver and calming wind. Indications are yin deficiency and wind-moving syndrome. In the late stage of epidemic febrile disease, the symptoms are mental fatigue, carbuncle, weak pulse, little red tongue coating, and sometimes the tendency to take off. [ 1]
The big wind-fixing beads of the two sides in the book Differentiation of Epidemic Febrile Diseases have the function of nourishing fluid and calming wind. Treatment of heat pathogen for a long time, heat burning true yin, or due to misuse of sweat, diarrhea, serious injury to vaginal fluid, mental fatigue and carbuncle, weak pulse, red tongue with little fur, and always want to take off. In modern times, it is often used in the late stage of Japanese encephalitis, and tremor paralysis belongs to yin deficiency and wind generation [2].
Indications: the syndrome of hyperactivity of liver wind due to sudden blindness is biased towards hyperactivity of wind due to yin deficiency [6].
7 Fang Jie Da Ding Feng Zhu is mainly used for the syndrome of yin deficiency and wind movement caused by prolonged febrile disease, pathogenic heat burning true yin, or due to accidental sweating, rash attack and serious injury of vaginal fluid. It is advisable to nourish yin and extinguish wind. In the prescription, gallus gallus domesticus brisson and Colla Corii Asini are the monarch, nourishing yin fluid to extinguish internal wind. Reuse Radix Paeoniae Alba, Radix Rehmanniae and Radix Ophiopogonis to nourish yin and soften liver, strengthen water and contain wood; Tortoise shell and turtle shell nourish yin and suppress yang, both of which are minister drugs. Maren is moist and fatty, nourishing yin and moistening dryness; Oysters are salty and cold, calming the liver and suppressing yang; Schisandra chinensis tastes sour and good, and it is mixed with all kinds of yin-nourishing drugs, but it converges to true yin, and it is matched with roasted licorice, and it also has the function of sour and sweet yin. The above drugs strengthen the effect of nourishing yin and calming wind, and * * * is the adjuvant. Glycyrrhiza uralensis Fisch harmonizes all kinds of medicines, and it is also a medicine. [ 1]
Dading wind beads are mainly Ejiao and gallus gallus domesticus brisson, which nourish yin and extinguish wind; Paeonia lactiflora, Schisandra chinensis and glycyrrhizic acid are sweet to yin, nourishing yin and softening liver; Rehmannia glutinosa, Ophiopogon japonicus and Hemp Seed nourish yin, nourish blood and moisten dryness; Tortoise shell, turtle shell and oyster nourish yin and suppress yang, and the whole prescription focuses on nourishing yin and suppressing yang and calming wind [6].
In Dading Fengzhu Formula, gallus gallus domesticus brisson and Ejiao nourishing yin and nourishing liquid take calming wind as the main drugs; Rehmannia glutinosa, Ophiopogon japonicus, Paeonia lactiflora, Carapax et Plastrum Testudinis, Carapax Trionycis and Oyster nourish yin and subdue yang, Radix Glycyrrhizae Preparata and Fructus Schisandrae Chinensis are sour to melt yin, and prevent the dissipation of qi and yin, and hemp seeds nourish yin and moisten dryness. All these drugs cooperate to have the effects of nourishing fluid and filling yin, softening liver and calming wind [2].
This prescription syndrome is caused by prolonged febrile disease, pathogenic heat burning true yin, or by accidental sweating, rash attack and serious injury to vaginal fluid. Due to the great deficiency of true yin, mental fatigue, weak pulse, crimson tongue with little fur, and sometimes the tendency to get rid of it. Yin deficiency means that water does not contain wood, so that deficiency wind moves inside, while hand, foot and carbuncle. At this time, the pathogenic factors have gone to 89, and only one or two of the true yin is left. Therefore, it is advisable to treat thick and nourishing drugs to nourish yin and nourish fluid, fill the exhausted true yin and calm down the virtual wind of internal movement. [4]
8 Application1.This prescription is a commonly used representative prescription for treating yin deficiency and wind-moving syndrome in the late stage of epidemic febrile disease. The main points of syndrome differentiation and treatment are deficiency of true yin, deficiency of wind moving inside, and fatigue of spirit, carbuncle, weak pulse and little red tongue coating [1].
2. Addition and subtraction: asthma and ginseng; Spontaneous sweating plus Os Draconis, Ginseng Radix and Wheat; Poria, ginseng and wheat are added to the fright. Covering asthma, spontaneous sweating and palpitation are all syndromes of qi deficiency, so ginseng is used to replenish qi and promote fluid production, keel and wheat are added respectively to stop sweating and soothe the nerves and calm the palpitation [1].
3. Caution in use: It is not suitable for those with deficient vaginal fluid but excessive pathogenic heat [1].
9 modern indications [4]
Indications: Late stage of febrile disease.
9. 1 Epidemic febrile diseases Most of the so-called epidemic febrile diseases refer to infectious diseases such as mumps, epidemic cerebrospinal meningitis, epidemic encephalitis B, epidemic hemorrhagic fever, plague, cholera, infectious mononucleosis, poliomyelitis, infectious viral hepatitis, scarlet fever, various septicemia, typhoid fever and other serious diseases in the category of epidemic febrile diseases. Clinically, most of these diseases are critical. When they enter the late stage, some of them are in a state of dying, and some of them are spared from death and enter the recovery stage. Clinically, most of them have organ dysfunction, including brain, heart, liver, kidney, lung, circulation and blood failure, and even mild ones are complicated with organ function damage, especially the virus-infected people's immune function is seriously damaged, nutrition and energy are lacking, fat and protein disorders, water, salt and electrolyte are lacking, and acid-base balance is unbalanced. The so-called carbuncle is spasm and convulsion, which are mostly caused by brain dysfunction. It can also be caused by electrolyte disorder, water and salt imbalance, acid-base imbalance and trace element deficiency. The so-called "weak pulse, always want to take off" is an endangered state such as severe dehydration, shock or serious failure of other organs such as heart and brain. Because of the wide range of epidemic febrile diseases, it can't correspond to modern medical diseases one by one, and the etiology and mechanism are difficult to go into details. This theory is for reference only.
10 pharmacological action of dadingfengzhu [7]
10. 1 Effect on metabolic function The yolk contained in the royal medicine Chicken Egg yolk can be used to extract lecithin. Lecithin is an essential substance to maintain the stability of colloidal solution in vivo, which can promote the combination of cholesterol and protein, reduce plasma cholesterol and reduce the infiltration of fat into blood vessel wall; It also contains calcium, phosphorus, iron, vitamin A, thiamine, riboflavin, nicotinic acid, a large number of fatty substances, various proteins and amino acids. Colla Corii Asini contains a large number of essential amino acids, and at the same time contains more than 20 kinds of macro and trace elements such as potassium, sodium, calcium, magnesium, iron, copper, aluminum, manganese, zinc, chromium, platinum, lead, nickel, silver, nickel, strontium, barium, titanium, zirconium and so on. Tortoise shell also contains a large number of amino acids necessary for human body, as well as trace elements such as chromium, manganese, copper, zinc, phosphorus, magnesium, iron, potassium, calcium, aluminum, sodium and strontium, among which strontium, zinc and copper are the highest. Carapax Trionycis contains a lot of collagen, Trionyx sinensis sugar and 17 kinds of essential amino acids, and also contains many trace elements such as calcium, sodium, potassium, copper, aluminum, manganese, zinc, phosphorus and magnesium. Adjuvant oyster contains a lot of amino acids, fatty acids, macro and trace elements mentioned above, as well as silicon, nickel, iodine, selenium, cobalt and molybdenum, and also contains a lot of vitamin A, vitamin B 1, vitamin B2, vitamin B6, vitamin D and vitamin E, etc. Radix Rehmanniae also contains more than 20 kinds of trace elements. These substances play a vital role in maintaining the body's metabolism, among which the most concentrated are potassium, sodium, calcium, magnesium, iron, copper, zinc, cobalt, manganese, selenium, chromium, aluminum, barium, phosphorus, titanium, strontium and so on. There are also a lot of vitamin A, vitamin B, vitamin C, vitamin E and various amino acids. Among them, calcium, magnesium, sodium and potassium maintain the excitability of neuromuscular. Calcium is not only involved in the process of osteogenesis and blood coagulation, but more importantly, it is an agonist of many enzymes and a messenger for regulating cell function. As a second messenger, intracellular calcium plays an important role in regulating muscle excitation-contraction coupling factor, hormone and neurotransmitter * * *-secretion coupling factor, and the main control medium of body temperature central set point. Magnesium is an auxiliary factor and agonist of many enzymes, which can start more than 300 kinds of enzymes. Besides participating in important metabolic processes in the body, magnesium is closely related to almost all aspects of life, such as the generation and transmission of nerve impulses and muscle contraction. Especially the regulation of magnesium on intracellular potassium, magnesium deficiency can lead to intracellular potassium escape, and at the same time induce hypocalcemia. At this time, there are many central nervous system dysfunction symptoms such as insanity and lethargy and cardiovascular symptoms such as arrhythmia in clinic. Iron is the main component of hemoglobin, myoglobin, cytochrome system, the main complex of electron transfer chain, peroxidase, etc. At the same time, it is an important element of the rate-limiting enzyme synthesized by catecholamine. When iron is deficient, not only anemia occurs, but also nervous system symptoms such as irritability and inattention occur. Zinc is related to more than 80 kinds of enzyme activities in vivo, such as carbonic anhydrase, DNA and RNA polymerase, etc. Many protein, such as trans-acting factors, steroid hormones and thyroid hormone receptors, have zinc finger structures formed by zinc, which play an important role in transcription regulation, so zinc deficiency will inevitably lead to metabolic disorders; At the same time, zinc also participates in the synthesis of growth hormone and promotes immune function. More importantly, zinc deficiency can seriously affect brain function and aggravate mental depression. Copper is the auxiliary group of many enzymes in the body, such as cytochrome oxidase, etc. Copper ion is indispensable in the process of transferring electrons to oxygen. In addition, monoamine oxidase and SOD are also enzymes containing copper. Copper deficiency will affect the activities of some enzymes, show neurological symptoms, cause anemia, cause myocardial damage and metabolic disorder, and make neutrophils and lymphocytes function low. Selenium is the active center of glutathione peroxidase (GSHPx), and each molecule of enzyme can combine with four selenium atoms. GSHPx can reduce toxic peroxide into nontoxic hydroxide by using H2O2 to protect cell membrane. At the same time, selenium can strengthen the antioxidant effect of vitamin E, and vitamin E can transform oxygen free radicals and hydroxyl free radicals (ROO) into non-toxic reproductive quinone, which has antioxidant effect. At the same time, selenium is also involved in the synthesis of coenzyme Q and coenzyme A. Selenium deficiency can often induce dilated heart disease and increase the incidence of cancer. When chromium is deficient, the decrease of insulin biological activity leads to atherosclerosis and stagnation of growth and development. Manganese is a component and active agent of many enzymes, such as RNA polymerase, SOD, etc. When manganese is deficient, it can directly affect brain function, make nervous system function disorder, affect reproductive function, and reduce the amount of insulin and pancreatic β cells. Cobalt is an important component of vitamin B 12, which has a direct impact on nerve function. At the same time, both cobalt and manganese are essential elements for the synthesis of thyroxine. Cadmium can detoxify lead.
Vitamin A can promote the absorption of fat, protein in food, bile salts and vitamin E in the body, and promote the growth of bones, skin and mucous membranes. Vitamin D can promote the absorption and metabolism of calcium and phosphorus, and promote bone growth. Vitamin B 1 is an essential substance for glucose metabolism. When it is deficient, glucose oxidation is blocked, and clinical neurovascular symptoms appear. Vitamin B _ 2 is a component of flavase auxiliary groups in the body, which affects the biological oxidation of the body and causes metabolic disorders when lacking. Vitamin E is a free radical scavenger, which directly participates in lipid metabolism and promotes the secretion of reproductive hormones. Vitamin B6 is a coenzyme of amino acid transferase, dehydrogenase and racemase, and directly participates in the metabolism of many amino acids.
At the same time, most of the herbs in the prescription are rich in nutrients, especially all kinds of amino acids and essential amino acids are the basic substances for the synthesis of protein and various enzymes in the body, and all kinds of sugars and fats are beneficial to the synthesis and metabolism of substances needed in the body.
The total glucosides of Paeonia lactiflora, a minister drug, can regulate serum lipid, MDA and TC/LDL, and can increase HDL at high dose. Rehmannia glutinosa and phenylethanoid glycosides contained in Rehmannia glutinosa can inhibit enzyme activity, and aldose reductase inhibitors are used to treat diabetic syndrome and reduce blood sugar. Ophiopogon japonicus and its polysaccharide have obvious hypoglycemic effect and can promote the functional recovery of islet cells. Tortoise shell can increase serum alkaline phosphatase activity, increase bone calcium and magnesium content and bone mineral density. Hemp seed oil can reduce serum total cholesterol, triacylglycerol, low density lipoprotein cholesterol (LDL) and increase serum high density lipoprotein cholesterol (HDL). Oyster can also reduce serum total cholesterol, triglyceride and LDL. Schisandra chinensis can promote the synthesis of DNA, RNA and protein in brain, promote the production of hepatic glycogen, and increase the content of cAMP in plasma and liver tissue. Glycyrrhiza uralensis Fisch also has the function of reducing blood lipid.
It can be seen that this prescription can promote and regulate protein metabolism, fat metabolism, glucose metabolism and the activities of various enzymes in the body.
10.2 effects on nervous and endocrine functions; gallus gallus domesticus brisson, the monarch drug, has the effects of strengthening the brain and strengthening the body. The official medicine Paeonia lactiflora and its total glucosides of Paeonia lactiflora can obviously inhibit the brain electrical activity and reduce the contents of calcium, sodium and water in the brain, thus reducing brain edema; At the same time, Paeonia lactiflora has sedative, hypnotic, analgesic and anticonvulsant effects, and can promote brain learning and short-term memory; More importantly, TGP has a biphasic regulating effect on hypothalamus-pituitary-adrenocortical axis according to the functional state of the body, so that it can coordinate various functions of the nervous and endocrine systems and restore the balance of the body. Total glucosides of paeony can also improve the brain's hypoxia tolerance. Rehmannia glutinosa not only has a central sedative effect, but also can reduce the effect of glucocorticoid on the function and morphology of pituitary-adrenocortical system, and increase the plasma corticosterone concentration. Ophiopogon japonicus decoction has sedative effect, has synergistic effect on the sedative and hypnotic effects of pentobarbital sodium and chlorpromazine, and antagonizes the exciting effect of coffee. Ophiopogon japonicus can enhance the function of pituitary-adrenal cortex system and improve the adaptability of the body. Tortoise shell can promote the proliferation of neural stem cells after focal cerebral ischemia, alleviate the symptoms of nerve injury, effectively reduce the thyroid function of hyperthyroidism patients, reduce the contents of T3 and T4 in serum, restore the growth of atrophic thyroid and reduce the thyroid function of hyperthyroidism patients; More importantly, turtle shell decoction can restore the growth of adrenal cortex, thicken the globular zone of cortex, increase the cell body of fascicular zone, enrich the cytoplasm and increase the weight of adrenal gland, which reduces the function of adrenal cortex in patients with hyperthyroidism. Adjuvant hemp seed has analgesic effect. Schisandra chinensis has an exciting effect on all levels of the central nervous system, and has an influence on the exciting and inhibiting processes of the cerebral cortex, so that it tends to be balanced. Therefore, it has an adjusting effect on the functions of the nervous system, can excite spinal cord reflex, strengthen the exciting and inhibiting processes of conditioned reflex, make the two processes tend to be balanced, and improve the regulating effect of the cerebral cortex, thus improving work efficiency and producing anti-fatigue effect; Schisandra chinensis seed ethanol also has obvious sedative effect, which can resist the central excitation of amphetamine, and has synergistic effect on the sedative and hypnotic effects of pentobarbital sodium and chlorpromazine. Pentanol also has anticonvulsant effect. Glycyrrhizic acid intravenous drip can improve the activities of ATPase and lactate dehydrogenase in brain mitochondria after complete ischemia reperfusion, and alleviate brain edema. At the same time, licorice FM 100 has sedative, analgesic and anticonvulsant effects. More importantly, it can stimulate hypothalamus-pituitary-adrenal cortex axis and enhance cortisol secretion.
It can be seen that this prescription not only has sedative and analgesic effects on the central nervous system, but also can reduce brain edema, protect brain cells and alleviate brain injury caused by ischemia/reperfusion. More importantly, the four herbs and 1 herb have consistent exciting and protective effects on hypothalamus-pituitary-adrenocortical axis, which increases the secretion and release of glucocorticoid and mineralocorticoid and the release of various endocrine hormones from pituitary, thus further regulating water and salt metabolism, fat and adrenal cortex. More importantly, the "permissive" function of glucocorticoid can coordinate other nerves and endocrine hormones in the whole body to play a role and restore the balance of various skills of the body. Mineralocorticoid regulates the metabolism of water and salt in the whole body, restores the balance of effective circulation, and reduces the loss, thus improving the syndrome of "pulse deficiency, always wanting to get rid of".
10.3 effect on immune function: Ejiao can promote lymphocyte transformation, promote NK cell function, increase phagocytosis percentage and phagocytosis index of macrophages, resist the inhibition of hydrocortisone on immune function, and improve the specific rosette rate of the body; At the same time, Ejiao can significantly improve the cold resistance of the body, and has anti-fatigue and anti-radiation effects. Paeonia lactiflora, a minister medicine, has a biphasic regulation effect on humoral immunity, cellular immunity and nonspecific immunity according to the state of the body, that is, those with enhanced immunity inhibit it and those with decreased immunity enhance it. Rehmannia glutinosa and its polysaccharides have obvious immune enhancement effect, which protects the immune function of the body by blocking some links of dexamethasone and cyclophosphamide. At the same time, Rehmannia glutinosa can obviously enhance DNA synthesis, protein and IL-2 production of lymphocytes induced by ConA. Ophiopogon japonicus can significantly increase the weight of spleen, enhance the phagocytosis of reticuloendothelial system, increase peripheral white blood cells, improve immune function, and antagonize the decrease of WBC caused by cyclophosphamide and 60Co irradiation. * * * Lysin production in serum. Tortoise shell can enhance humoral immune function and cellular immune function, and its decoction can increase lymphocyte transformation rate and antibody IgG in blood, enhance phagocytosis of macrophages, and antagonize the damage and inhibition of immune organ function. Trionyx sinensis can significantly improve cellular immune function, promote lymphocyte transformation and improve phagocytosis of macrophages. Adjuvant oyster can significantly improve immune function, and oyster water extract can significantly improve macrophage phagocytosis and lymphocyte transformation rate; Oyster hot water extract can significantly increase the number of spleen antibody-producing cells and the antibody. Schisandra chinensis has similar adaptation to ginseng, which can enhance the body's defense ability against nonspecific * * *; The crude polysaccharide of Schisandra chinensis can improve the nonspecific immune function and increase the number of WBC in peripheral blood. Schisandra chinensis oil emulsion can promote cellular immune function and promote DNA synthesis of lymphocytes; Pentanol has inhibitory effect on immune function, humoral immune function and cellular immune rejection. The glycyrrhizic acid contained in Glycyrrhiza uralensis Fisch can enhance the activity of NK cells, induce interferon, enhance the activity of reticuloendothelial system and promote the weight increase of spleen and thymus. Glycyrrhiza polysaccharide can improve the function of reticuloendothelial system and monocytes; Glycyrrhizin can enhance IL-2 secretion ability of lymphocytes induced by ConA, inhibit mast cell degranulation, and inhibit histamine release induced by IgE and ConA compound 48/80. Licorice Lx can reduce antigen amount, thus having anti-allergic effect. Glycyrrhetinic acid can increase the lymphocyte ratio, β glycyrrhetinic acid is an inhibitor of the classical pathway of human complement, and monoamine glycyrrhizinate can increase the level of INFα.
To sum up, all kinds of traditional Chinese medicines in this prescription have the same promotion and regulation effects on immune function, which is a very important treatment measure for low immune function and inhibition in the late stage of various epidemic febrile diseases.
10.4 influence on heart, circulation and blood function. Colla Corii Asini, a monarch drug, can increase the permeability of disease-resistant blood vessels, reduce plasma exudation, maintain the effective circulation to a certain extent, help to restore microcirculation blood perfusion to normal, improve hemodynamics, and make blood pressure return to normal quickly for hemorrhagic shock, anaphylactic shock and endotoxic shock. Ejiao can promote hematopoietic function and make hemoglobin, red blood cells and white blood cells of anemia patients return to normal quickly; Ejiao contains collagen, which is sticky and can be attached to the surface of capillaries, shortening the time of blood coagulation and stopping bleeding. The minister drug Paeonia lactiflora and its total glucosides can increase myocardial nutritional blood flow, antagonize myocardial ischemia caused by pituitrin, dilate blood vessels and lower blood pressure; The extract of Radix Paeoniae Alba has inhibitory effects on enkephalin receptor, α adrenoceptor, angiotensin Ⅱ receptor, β hydroxyβ methylglutaric acid coenzyme A, etc. In different degrees, it can also inhibit platelet aggregation induced by ADP and arachidonic acid, reduce the wet weight of platelets and inhibit thrombosis. Rehmannia glutinosa has a cardiotonic effect, and it has a more obvious effect on the weak heart. At the same time, it can dilate renal blood vessels and has a diuretic effect. Rehmannia glutinosa has antihypertensive effect by increasing cAMP and decreasing cGMP/cAMP ratio; Rehmannia glutinosa and Rehmannia glutinosa polysaccharide can promote bone marrow hematopoiesis, obviously improve the colony-forming unit rate of myelomonocytic progenitor cells, and promote the recovery of myelomonocytic progenitor cells caused by cyclophosphamide and radiation. Ophiopogon japonicus and its saponin can obviously enhance myocardial contractility and cardiac output, and increase coronary blood flow, but high dose can inhibit it. Ophiopogon japonicus injection can improve left ventricular function and anti-shock, reverse the inhibitory effect of hemorrhagic shock on cardiac function, improve circulation and raise blood pressure. Ophiopogon japonicus injection can obviously reduce the hypoxic damage of myocardial cells, narrow the range of myocardial infarction and necrosis, increase the nutritional blood flow of myocardial infarction, and repair and protect ischemic and hypoxic myocardial cells quickly, which has anti-arrhythmia effect. Ophiopogon japonicus total saponins can also act on sodium and calcium channels of myocardial cells, reduce the influx of Na+ and Ca2+ outside myocardial cells, reduce the self-discipline of myocardial cells, slow down conduction, and help one-way block to become two-way block to eliminate reentry excitement. Tortoise shell can increase coronary blood flow, improve myocardial hypoxia tolerance, and has anti-arteriosclerosis effect. Carapax Trionycis can significantly increase hemoglobin and promote hematopoietic function. Hemp seed tincture has the effect of lowering blood pressure after ethanol is removed and made into emulsion. Oyster extract has anti-atherosclerosis effect. The water extract of Schisandra chinensis can block myocardial β 1 receptor, weaken myocardial contractility and slow heart rate, at the same time, it can increase the activity of RNA and metabolic enzymes in myocardial cells, and strengthen and regulate cell energy metabolism. Improve myocardial nutritional function; At the same time, Schisandra chinensis can improve coronary blood flow and relax vascular smooth muscle. So that the licorice flavone contained in the medicinal licorice has antiarrhythmic effect; Glycyrrhetinic acid has the agonist-like effect of angiotensin ⅡAT 1 receptor, which can reduce the range of myocardial infarction. Glycyrrhizin can cause reactive blood pressure increase, and licorice has anti-atherosclerosis effect.
It can be seen from the above that all Chinese herbs in this prescription can improve myocardial function, promote circulatory function and have hematopoietic function, which is especially important for the treatment of severe anemia and cardiac dysfunction in the late stage of epidemic febrile disease.
10.5 Anti-inflammatory and antioxidant effects The total glucosides of Paeonia lactiflora can inhibit the excessive secretion of IL 1, TNF and PGE2. Paeonia lactiflora has significant anti-inflammatory effects on various experimental nonspecific inflammation and immune inflammation, and has different inhibitory effects on capillary permeability, exudation, edema and proliferation of inflammation. Total glucosides of Paeonia lactiflora and Paeonia suffruticosa can significantly inhibit the oxidative hemolysis of RBC caused by H2O2, scavenge oxygen free radicals and hydroxyl free radicals, and inhibit the formation of LPO. Rehmannia glutinosa has anti-inflammatory and repercussive effects, and Rehmannia glutinosa can also enhance GSHPx activity and reduce LPO content. Ophiopogon japonicus decoction can significantly improve erythrocyte SOD activity, serum total antioxidant capacity, GSHPx activity and serum MDA content, and has a strong scavenging effect on reactive oxygen free radicals. Copper is the catalyst of oxidation-reduction system, and tortoise plastron decoction can resist the increase of serum copper in patients with hyperthyroidism and yin deficiency, so it has antioxidant effect. Adjuvant hemp seed also has anti-inflammatory effect, which can inhibit the increase of vascular permeability of inflammation. Schisandra chinensis and its various components have protective effects on the damage caused by oxygen free radicals. Schisandrin can directly scavenge oxygen free radicals, significantly inhibit the decrease of myocardial mitochondrial membrane fluidity caused by adriamycin, significantly inhibit the production of malondialdehyde caused by adriamycin in the presence of Fe2+, and inhibit erythrocyte hemolysis and membrane lipid peroxidation caused by hydrogen peroxide, significantly increase the activities of SOD and GSHPx in serum, and reduce the contents of LPO and MDA. Glycyrrhiza uralensis Fisch has anti-inflammatory effects like phenylbutazone and hydrocortisone, and has inhibitory effects on inflammatory stages I, II and III, as well as immune inflammation. Glycyrrhizic acid and glycyrrhetinic acid can also inhibit the production of free radicals and lipid peroxide, and have antioxidant effects.
10.6 Influence on Pathogenic Microorganisms The decoction of Paeonia lactiflora, a Chinese medicine, has inhibitory effects on many pathogenic bacteria, such as Shigella dysenteriae, Escherichia coli, Staphylococcus, Pseudomonas aeruginosa, etc. It also has inhibitory effect on many fungi, and also has direct antiviral effect. Rehmannia glutinosa water extract has inhibitory effect on many fungi such as tinea pedis. Ophiopogon japonicus can inhibit many kinds of bacteria, such as Staphylococcus albus, Bacillus subtilis, Escherichia coli and typhoid Bacillus. Schisandra chinensis has inhibitory effects on Staphylococcus aureus, Pneumonia, Salmonella enterica and Pseudomonas aeruginosa. Glycyrrhiza uralensis Fisch not only has inhibitory effect on some of the above bacteria, but also has inhibitory effect on Streptococcus B, Pseudomonas aeruginosa and Helicobacter pylori, and also has broad-spectrum antiviral effect. Glycyrrhrizae Radix polysaccharide also has inhibitory effects on vesicular stomatitis virus, herpes simplex virus type I and vaccinia virus. Glycyrrhizic acid has strong inhibitory ability on coxsackie virus, adenovirus and syncytial virus. Monoamine glycyrrhizinate can inhibit HIV, and glycyrrhizin can inhibit hepatitis virus in addition to the above viruses. The hot water extract of Glycyrrhiza uralensis Fisch can kill Clonorchis sinensis, while Glycyrrhiza uralensis Fisch can kill mycobacterium tuberculosis, amoeba and trichomonas.
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Effect of 10.7 on digestive system function; Paeonia lactiflora, a Chinese medicine, has protective effects on various experimental liver injuries, can resist eosinophilic degeneration and necrosis of liver tissues, and also has protective effects on immune liver injuries; Paeonia lactiflora decoction can inhibit pancreatic amylase activity, paeoniflorin and paeonol can inhibit gastric acid secretion, and have anti-ulcer effect, which has a coordinated effect when combined with licorice FM 100; Paeonia lactiflora and Glycyrrhiza uralensis Fisch can inhibit the release of acetylcholine from parasympathetic nerve endings and have obvious spasmolytic effects. Rehmannia glutinosa decoction can also protect liver cells, prevent the decrease of glycogen, and protect gastric mucosa from injury. Ophiopogon japonicus decoction can inhibit gastrointestinal propulsion. Biejia decoction has anti-hepatic fibrosis effect. The hemp seed has the functions of benefiting gallbladder, promoting bile secretion and resisting ulcer. Oyster can inhibit gastric acid secretion, reduce pH and pepsin activity, and has anti-ulcer effect. Schisandra chinensis decoction has protective effect on liver injury. Schisandra chinensis can promote the biosynthesis of protein and glycogen in liver cells and accelerate the repair and regeneration of liver cells. Schisandrin A, Schisandrin B, and Schisandrin C can significantly increase the content of cytochrome P450 in liver microsomes, promote the synthesis of hepatic drug enzymes, and enhance the activity of hepatic drug enzymes, thus enhancing the detoxification ability of the liver. Schisandra chinensis can improve the activities of SOD and CAT in liver, improve the function of glutathione oxidation system in liver, reduce the damage of oxygen free radicals to liver cells, inhibit lipid peroxidation in liver microsomes, reduce the production of MDA, protect the structural integrity and normal function of liver cell membrane, enhance the function of adrenal cortex, and reduce the inflammatory reaction of liver cells. Therefore, Schisandra chinensis can significantly reduce hepatocyte necrosis, prevent hepatic steatosis, resist liver fibrosis, reduce ALT and AST, and significantly improve liver function. At the same time, Schisandrin can inhibit gastric acid secretion. The drugs such as Glycyrrhiza uralensis Fisch, glycyrrhizic acid, glycyrrhetinic acid, glycyrrhizin, etc. have the function of protecting liver, and can inhibit hepatic steatosis and hepatic fibrosis; It can promote bile secretion, has anti-ulcer effect and spasmolytic effect at the same time. Glycyrrhiza FM 100 has papaverine-like spasmolytic effect.
1 1 Song formula Dading Fengzhu gallus gallus domesticus brisson, and then add and subtract Fumai Decoction; The combination of Sanjia and Schisandra chinensis, nourishing yin and calming wind is a wonderful prescription. [ 1]
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