The prescription uses gentian grass, which is bitter and cold. It can purge excess fire in the liver and gallbladder. It can clear the dampness and heat in the lower burner. It is the king medicine of this prescription for purging fire and dehumidification.
Scutellaria baicalensis and gardenia have bitter cold and purge fire. For its merit, Gentian grass is used as a ministerial drug in this prescription. Alisma, Tong, Plantain Seed clears away heat and promotes dampness, so that dampness and heat can be eliminated from the waterways. The liver stores blood, and there is heat in the liver meridian. It is easy to consume the yin blood. In addition, it is bitter and cold to dry dampness, and then consumes the yin. It is used in ancient times. Angelica sinensis nourishes yin and blood, and is used as an auxiliary medicine. Bupleurum in the prescription is used to guide various drugs into the meridians of the liver and gallbladder. Licorice has the effect of harmonizing various drugs.
Most of the drugs in this prescription are bitter and cold in nature. Each medicine contained in the prescription may damage the spleen and stomach, so it is not suitable for It is not suitable to take it for a long time if the spleen and stomach are weak or cold, or if you take it too much or for a long time
This prescription cannot be taken for a long time. Drugs containing Aristolochia have been banned. The Akebia now on the market is Akebia acuta
Akebia
Mutong
This product It is the dried cane of Akebia quinata (Thunb.) Decne., Akebia trifoliate (Thunb.) Koidz. or Akebia trifoliata (Thunb.) Koidz.var.australis (Diels) Rehd. .
Processing: Remove impurities from the original drug, wash, moisten, cut into thin slices, dry, and sieve to remove dust.
Characteristics: This product is a round piece with a diameter of 1 to 2cm. The surface is gray-brown to gray-brown, with raised lenticels and side branch marks visible. The bark on the cut surface is yellow-brown, fibrous, and thick, the wood is yellow-white or off-white, and the pith is small or hollow. The body is light and the quality is solid. The smell is slight and the taste is slightly bitter.
Identification: Take oleanolic acid reference substance and helexin reference substance, add methanol to make a solution containing 0.2mg per 1ml, as the reference solution. According to the thin layer chromatography test (Appendix VI B of the 2005 edition of the Chinese Pharmacopoeia), absorb 10 μl each of the test solution under [Content Determination] and the above two reference solution solutions, and spot them on the same silica gel G thin layer plate. On the surface, use n-hexane-ethyl acetate-glacial acetic acid (6:4:0.25) as the developing agent, unfold, take out, dry, spray with 10% sulfuric acid ethanol solution, and heat at 105°C until the spots are clear. In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the reference substance.
Check the moisture content according to the moisture determination method (Method 1 of Appendix IX H of the 2005 edition of the Chinese Pharmacopoeia), and it shall not exceed 10.0%.
The total ash content shall not exceed 6.5% (Appendix IX K of the 2005 edition of "Chinese Pharmacopoeia").
Content determination: Determine according to high performance liquid chromatography (Appendix VI D of the 2005 edition of the Chinese Pharmacopoeia).
The chromatographic conditions and system suitability test used octadecylsilane bonded silica gel as the filler; methanol-water-glacial acetic acid-triethylamine (87:13:0.04:0.02) as the mobile phase ;The detection wavelength is 210nm. The number of theoretical plates calculated for oleanolic acid peaks should be no less than 2,000.
Preparation of reference substance solution: Precisely weigh appropriate amounts of oleanolic acid reference substance and ivy saponin reference substance, add methanol to prepare a mixed solution containing 1mg each per 1ml.
Preparation of test solution: Take about 2g of this product powder (passed through No. 4 sieve), weigh it accurately, add 50ml of methanol, ultrasonicate (power 250W, frequency 50kHz) for 30 minutes, filter and remove the residue Wash with an appropriate amount of methanol, combine the filtrate and washing liquid, recover the solvent to dryness, dissolve the residue in 10 ml of water, shake and extract with saturated n-butanol three times, 20 ml each time, combine the extracts, evaporate to dryness, add 20 ml of methanol and 2 ml of hydrochloric acid to the residue , heat and hydrolyze for 4 hours, add 10ml of water to the hydrolyzate, shake and extract twice with chloroform, 20ml each time, combine the extracts, recover the solvent to dryness, dissolve the residue with methanol and transfer to a 10ml measuring bottle, add methanol to the mark , shake well, filter, and take the remaining filtrate to get it.
Measurement method: Precisely draw 20 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.
Calculated as a dry product, the total content of oleanolic acid (C30H48O3) and helexin (C30H48O4) in this product shall not be less than 0.10%.
Nature, flavor and meridians: Bitter, slightly cold. Guixin, small intestine, bladder and intestines.
Functions and Indications: Clear heart fire, facilitate urination, stimulate menstruation and release breast milk. It is used for troublesome heat in the chest, sore throat, red urine, stranguria, edema, contracture and pain all over the body, amenorrhea and lack of breast milk.
Usage and dosage 3~6g.
Storage Store in a dry place.
Contained from the 2005 Shanghai Processing Standards