The efficacy of safflower:
Indications: promoting blood circulation, removing blood stasis and relieving pain. Used for amenorrhea, dysmenorrhea, lochia, abdominal mass and traumatic injury. The ancients often used a small handful of safflower when the blood was in the body: the gauze bag can be boiled twice a day to soak the feet, which is suitable for all kinds of varicose veins, peripheral neuritis and blood circulation. Activating blood and activating meridians; Removing blood stasis and relieving pain, safflower is pungent and warm, and it returns to the heart and liver meridian. Qi-Xiang-Xing-San and blood-Qi-Xing-fen have the effects of promoting blood circulation, dredging channels, removing blood stasis and relieving pain, and are mainly used for treating dysmenorrhea, amenorrhea, postpartum blood halo, abdominal pain due to blood stasis, chest pain, blood stasis, bruises from falls, joint pain, paralysis due to apoplexy, and purple rash.
The function of safflower:
Effects on cardiovascular system:
1. 1. Inhibition of cardiac function:
Small dose of safflower decoction can make toad heart slightly excited in vitro and rabbit heart in vivo, make the heartbeat strong and increase the amplitude; High dose has an inhibitory effect on the heart, slowing down the heart rate, weakening the myocardial contractility and reducing the cardiac output.
1.2. The experimental study on coronary blood flow shows that:
Carthamus tinctorius water extract and Carthamus tinctorius water-soluble mixture-safflower yellow can increase coronary blood flow and myocardial nutritional blood flow; However, the effect of ethanol extract of safflower on dilating coronary artery and increasing coronary blood flow is not obvious or has no effect.
1.3. Experimental research on experimental myocardial ischemia and myocardial infarction shows that:
Carthamus tinctorius and its preparations have different degrees of antagonistic effects on experimental myocardial ischemia or myocardial infarction in rabbits, rats and dogs. Safflower can protect acute myocardial ischemia caused by pituitrin in rats or rabbits. It can obviously reduce the degree, range and heart rate of acute myocardial ischemia in anesthetized dogs caused by repeated short-term blocking of coronary blood flow, and protect the edge and area of acute myocardial infarction to reduce the infarct range and reduce the elevation of ST segment of ECG in the edge area, thus improving the supply and demand relationship of oxygen in ischemic myocardium.
1.4. The study on the effect of safflower on blood vessels found that:
For example, if the blood vessels are perfused with Rockwell's solution containing trace adrenaline or norepinephrine, the isolated vascular smooth muscle of animals will contract to maintain a certain vascular tension, resulting in a state of blood stasis that may be similar to that of people. Carthamus tinctorius can dilate the blood vessels in the hind limbs and ears of guinea pigs with increased tension, and the effect is obvious with the increase of dosage. Carthamus tinctorius can also increase the blood flow of femoral artery in anesthetized dogs, but it can contract the normal isolated blood vessels of toads and rabbits. It shows that the vasodilating effect of safflower is related to the functional state of blood vessels and the dose of drugs. Its mechanism may be that it directly or partially antagonizes the action of a- adrenergic receptor to dilate blood vessels, and has a weak direct contraction effect.
1.5. Effect of safflower on cerebral edema caused by ischemic stroke in experimental animals;
Carthamus tinctorius injection (1ml containing crude drug lg) was given to 63 Mongolian gerbils by ip 30 minutes before operation, and the operation control group and sham operation group were established to observe the effect of Carthamus tinctorius on ischemic brain edema and study the changes of monoamine neurotransmitters in the same brain region. The results suggest that the mechanism of safflower alleviating ischemic brain edema may be related to its influence on the metabolic disorder of monoamine neurotransmitters in tissues. It is further confirmed that safflower can indeed reduce the incidence and mortality of stroke and protect the brain tissue of experimental chest infarction animals.
1.6. antihypertensive effect:
Carthamus tinctorius decoction, Carthamus tinctorius yellow pigment and other preparations have different degrees of rapid hypotensive effect on anesthetized cats or dogs. The average blood pressure drops by about 20 minutes Hg, and then recovers after about 30 minutes.
1.7. The experimental study on the anticoagulant effect of safflower yellow showed that:
Carthamus tinctorius yellow has a very significant inhibitory effect on ADP-induced platelet aggregation in rabbits, and also has a very obvious depolymerization effect on ADP-induced platelets. When the dosage was 0.22g/ml, the aggregation inhibition rate and depolymerization percentage reached 85.9% and 78.9% respectively. These effects of safflower yellow pigment are enhanced with the increase of dose. Safflower yellow has a very significant inhibitory effect on experimental thrombosis in rats, and its inhibitory rate is 73.4%. Because the thrombus formed on silk thread is based on platelet aggregation, the reduction of wet weight of thrombus is obviously the result of drug inhibiting platelet aggregation. It is consistent with the fact that safflower yellow can inhibit platelet aggregation induced by ADP in vitro. Safflower yellow can obviously prolong the plasma calcium recovery time, prothrombin time and coagulation time of rabbits. It shows that it can affect the coagulation system both in vivo and in vitro. In addition, safflower oil has the effect of lowering blood lipid.