Metro Line 6 and Metro Line 5. According to Baidu map query, Guangzhou Second Children's Palace is located in the south section of Zhujiang New Town, the new center of Guangzhou city, with South China Road in the south and Yuexiu South Road 8.8 kilometers away from this location. It takes 35 minutes to get there by subway lines 6 and 5. The specific bus route is:

1. First, walk 420 meters from Yuexiu South Road to Tuanjie Square Station, and take Metro Line 6 (Xiangxue direction) to Ouzhuang Station.

2. Secondly, transfer to Metro Line 5 (direction of Wenchong) and arrive at Zhujiang New Town Station (exit C of R&F Center).

Finally, walk 600 meters to the Second Children's Palace in Guangzhou.