The routes taken are different.
Because from Wuhan to Chengdu, you will pass through Macau Road, Hong Kong Road, Airport Second Channel, Hurong Expressway, Zhangnan Expressway, etc., while from Chengdu to Wuhan, you will pass through Jinyue West Road, Zhuojin Interchange, The routes taken by the Shanghai-Chongqing Expressway are different, and the scenery and meals along the way are different. Each place has its own characteristics.
You can take trains from Wuhan to Chengdu. The trains include K532, which runs for 21 hours; T128, which runs for 16 hours and 15 minutes; and D367, which runs for 9 hours and 3 minutes.