Summarize that Evodia rutaecarpa is a processed product of Coptis chinensis, and the method is Evodia rutaecarpa. Coptidis Rhizoma has been processed in the Tang Dynasty. See "Qianjin Yifang". Coptis chinensis Franch, Coptis chinensis Franch, Coptis deltoidea C.Y. Cheng et Hsiao or Coptis teeta Wall. of Ranunculaceae [1]. Coptidis Rhizoma is bitter in taste, cold in nature, and enters the heart, spleen, stomach, liver, gallbladder and intestines. It has the effects of clearing away heat, eliminating dampness, purging fire and detoxicating, and can be used for damp-heat fullness, vomiting, acid swallowing, diarrhea, jaundice, high fever, hyperactivity of heart fire, insomnia, palpitation and restlessness, vomiting due to blood heat, red eyes, toothache, thirst quenching, etc. External treatment of eczema, wet sores, ear canal pus. Evodia rutaecarpa is dark yellow in color, bitter in taste, and slightly pungent in Evodia rutaecarpa. Evodia rutaecarpa can inhibit its bitter and cold nature, and make Coptis chinensis cold without stagnation, mainly by clearing away qi, dispersing damp-heat and dispersing stagnation of fire in liver and gallbladder [1].
3 Processing methods of Wuyulian In Tang Dynasty, there were methods of moistening, cutting and boiling (frying) (Qianjin Yifang) [1].
The processing method in Song Dynasty developed greatly, except for the frying method in Tang Dynasty. There are also micro-fried (Taiping Shenghui Recipe), fried coke (Boji Recipe, Charcoal-making (The Recipe Recorded in History), wine-fried (Bian Que's Heart Book), wine-steamed (Danxi Heart Method), ginger-fried (Hostel Preparation Recipe), honey-made (Taiping Huimin Hejiju Recipe), and so on.
In the Yuan Dynasty, methods such as local frying ("Danxi Heart Method") and toilet system ("Original Machine Reveals Micro") were added [1].
After the Ming and Qing Dynasties, vinegar system, salt system, milk system, baking soda system, dry lacquer system (Meng Ru), cornus Yizhi system (Compendium of Medicine), loess ginger wine honey system (Materia Medica), bile system, fried Sophora japonica flower system (Jingyue Quanshu) and wine dogbane system (Supplementing Wanbing Rejuvenation) were added. The purpose of its processing is expounded, such as "Coptis chinensis enters the hands of Shaoyin Heart Meridian, which is the main medicine for treating fire;" Cure the fire of dirty, then use it; To cure the fire of the liver and gallbladder, it is fried with pig bile; To cure the scorching fire, grind salt water or mirabilite to adjust water and stir fry; To treat the fire of damp and heat, stir-fry with cornus soup; To treat blood stagnation in blocks, stir-fry with dry paint powder; To cure the fire of food accumulation, grind loess to adjust water and stir fry "(Compendium of Materia Medica) [1]. "White dysentery is fried with cornus, red dysentery is fried with wet Sophora japonica, and Sophora japonica is removed" (Notes on Awakening Zhai Guang First) [1].
At present, the main processing methods are wine roasting, ginger roasting and Evodia rutaecarpa roasting [1].
The preparation method of Huanglian tablets: taking the original medicinal materials, removing impurities, washing with water, moistening thoroughly, slicing, drying, and sieving to remove debris; Or mashed in time [1].
The processing method of Evodia rutaecarpa L. is: decocting Evodia rutaecarpa L. with appropriate amount of water, taking the juice to remove residues, mixing the decoction with Huanglian tablets evenly, slightly moistening, placing the decoction in a frying container after it is exhausted, heating it with slow fire, frying it to dryness, taking it out, cooling it, and sieving off the debris [1].
Use Evodia rutaecarpa 10kg[ 1] for every 100kg of yellow slices.
4. The yellow patches of Evodia rutaecarpa are irregular thin slices or fragments, with dark yellow and rough periphery, rich residual fine fibrous roots and one-sided yellow [1]. Hard, slightly gassy and extremely bitter [1].
Evodia rutaecarpa is dark yellow in color, bitter in taste and slightly spicy in Evodia rutaecarpa [1].
5. The quality of Wuyulian requires that the total ash content of Rhizoma Coptidis should not exceed 5.0%, and the berberine content should not be less than 3.6% based on berberine hydrochloride (C20H17NO2 HCl); The total ash content of Evodia rutaecarpa should not exceed 4.0%[ 1].
6. The taste of Coptis chinensis belongs to Pharmacopoeia of the People's Republic of China (20 10 edition): Coptis chinensis is bitter in taste and cold in nature. Heart, spleen, stomach, liver, gallbladder and large intestine meridian.
Dictionary of Traditional Chinese Medicine: Coptis chinensis is bitter in taste and cold in nature. Into the heart, liver, stomach and large intestine.
Chinese Materia Medica: Coptis chinensis is bitter in taste and cold in nature, and enters the heart, liver, stomach and large intestine meridians.
Shennong's Classic of Materia Medica: "Bitter taste, cold."
Wu Pu's Materia Medica: "Shennong, Qibo, Leigong: bitter, non-toxic, Li: slight cold."
Herbal Decoction: "Start with Shaoyin Meridian."
"Shushu of Materia Medica": "Start with Shaoyin and Yangming, and foot with Shaoyang, Jueyin, Yangming and Taiyin."
Interpretation of Materia Medica: "Entering the Kidney Meridian of Foot and Heart Meridian of Hand with Less Yin.
7 Efficacy and Indications of Coptis chinensis "Pharmacopoeia of the People's Republic of China" (20 10 edition):
Coptis chinensis has the effects of clearing heat, eliminating dampness, purging fire and detoxifying. It can be used for treating sores such as fullness due to damp heat, vomiting, acid swallowing, diarrhea, jaundice, coma due to high fever, hyperactivity of heart fire, insomnia, palpitation, hematemesis, red eyes, toothache, thirst quenching and carbuncle swelling. External treatment of eczema, wet sores, ear canal pus.
Wine Huanglian is good at clearing and burning. Used for red eyes and aphtha.
Turmeric even clears stomach and stops vomiting. Used for cold and heat, damp-heat obstruction, fullness and vomiting.
Wuyulian soothes the liver and stomach to stop vomiting. Used for disharmony between liver and stomach, vomiting and acid swallowing.
Processing of traditional Chinese medicine;
Coptidis Rhizoma has the functions of purging fire, detoxicating, clearing away heat and eliminating dampness, and can be used for treating fullness due to damp-heat, vomiting, diarrhea, jaundice, coma due to high fever, excessive heart fire, insomnia, vomiting due to blood heat, red eyes, toothache, thirst quenching, carbuncle swelling and furuncle; External treatment of eczema, wet sores, ear canal pus [1]. For example, Huanglian Jiedu Decoction (Authentic Surgery) for treating toxic heat, dysphoria due to high fever and carbuncle and furuncle; Qingwen Baidu drink for treating qi and blood burn ("epidemic rash"); Pulsatilla decoction for diarrhea due to heat dysentery (Treatise on Febrile Diseases) [1].
Sauté ed Rhizoma Coptidis with wine can induce medicine to ascend, slow down its coldness and clear the fire of the leader [1]. For example, Huanglian Trichosanthes Pill (Criterion of Syndrome Differentiation and Treatment) for treating red eyes, swelling and pain and sores on the mouth and tongue [1].
Rhizoma Coptidis roasted with ginger can relieve its bitter and cold nature and enhance its antiemetic effect [1]. For example, Xiang Jiang San (Criterion of Syndrome Treatment) is used to treat damp-heat obstruction, stomach disharmony, vomiting and diarrhea; Yulian Pill for treating hypochondriac pain, belching, acid regurgitation and diarrhea due to heat in stool (Sichuan Provincial Drug Standard 1983) [1].
Rhizoma Coptidis prepared from Evodia rutaecarpa inhibits its bitter and cold nature, making Rhizoma Coptidis cold but not stagnant, mainly by clearing qi, dispersing damp heat and dispersing depressed fire in liver and gallbladder [1]. For example, Daxianglian Pill (Taiping Huimin Heji Ju Fang) [1] is used to treat stagnation of internal resistance, fullness of chest and diaphragm, fullness of hypochondriac ribs or diarrhea and purulent blood.
Dictionary of Traditional Chinese Medicine: Coptis chinensis has the effects of purging fire, eliminating dampness, detoxifying and killing insects. Treatment of heat toxin, typhoid fever, dysphoria due to excessive heat, nausea, bacillary dysentery, diarrhea and abdominal pain due to heat, lung obstruction, vomiting, dysentery, blood loss, thirst quenching, malnutrition, ascariasis, whooping cough, sore throat, flaming eyes, aphtha, carbuncle, eczema, and soup fire.
Chinese Materia Medica: Rhizoma Coptidis has the effects of clearing away heat and purging fire, eliminating dampness and detoxifying. Hyperpyrexia, dysphoria, delirium or vomiting caused by excessive heat forcing blood to move rashly, damp-heat chest swelling, diarrhea, dysentery, upset and insomnia caused by excessive heart fire, vomiting due to stomach heat or hunger, red eyes and swelling due to liver fire, hot toxic ulcer, jaundice due to furuncle, swollen gums, sores on the mouth and ears, etc.
Shennong's Classic of Materia Medica: "The main heat causes eye pain, canthus tears, eyesight improvement, abdominal pain and diarrhea in the intestine, and the woman is swollen and painful in the yin."
Notes on Materia Medica Classics: "Relieve Croton Poison."
"A Record of Famous Doctors": "Administer cold and heat in five zang-organs, relieve pus and blood for a long time, quench thirst and panic, remove water bones, regulate stomach and intestines, benefit gallbladder and treat aphtha."
"Theory of Medicinal Properties": "Kill infantile scabies, dull eyes and faint pain, calm the liver and remove heat and toxin."
"Compendium of Materia Medica": "The master is thin and short of breath."
"Rihuazi Materia Medica": "Treat five strains and seven injuries, replenish qi, and stop heart and abdominal pain. "fright and irritability, moistening the heart and lungs, gaining weight, stopping bleeding, complicated with boils and scabies, night sweats, hot weather and steaming pig's belly into pills, treat infantile malnutrition."
"Ren Zhai Zhi Zhi Fang": "You can get rid of evil blood."
"Pearl Capsule": "Purging the fire in the heart makes the heart swell. "Stir-fried in wine, soaked in wine, and the neck is on."
Wang Haogu: "The main heart disease is rebellious and prosperous, and the heart accumulates."
"Supplement to Materia Medica": "Stir-fried with ginger juice, dispelling heat with pungent flavor."
Compendium of Materia Medica: "Relieve the boredom and mild powder toxicity caused by taking drugs."
New edition of Materia Medica: "Stop vomiting and swallowing acid, relieve thirst, cure fire eyes, set your mind at ease, stop wet dream, be manic and eliminate fullness."
Compendium of Materia Medica: "Treating carbuncle, carbuncle, scabies, alcoholic intoxication and fetal poisoning. "Kill the octopus."
8 Processing effect of Wuyulian Coptidis Rhizoma has the functions of purging fire and detoxicating, clearing away heat and eliminating dampness, and can be used for damp-heat fullness, vomiting, diarrhea, jaundice, dizziness due to high fever, hyperactivity of heart fire, insomnia, vomiting due to blood heat, red eyes swallowing acid, toothache, thirst quenching, carbuncle swelling and furuncle; External treatment of eczema, wet sores, ear canal pus [1]. For example, Huanglian Jiedu Decoction (Authentic Surgery) for treating toxic heat, dysphoria due to high fever and carbuncle and furuncle; Qingwen Baidu drink for treating qi and blood burn ("epidemic rash"); Pulsatilla decoction for diarrhea due to heat dysentery (Treatise on Febrile Diseases) [1].
Rhizoma Coptidis prepared from Evodia rutaecarpa inhibits its bitter and cold nature, making Rhizoma Coptidis cold but not stagnant, mainly by clearing qi, dispersing damp heat and dispersing depressed fire in liver and gallbladder [1]. For example, Daxianglian Pill (Taiping Huimin Heji Ju Fang) [1] is used to treat stagnation of internal resistance, fullness of chest and diaphragm, fullness of hypochondriac ribs or diarrhea and purulent blood.
9 Study on the Processing of Coptis chinensis Franch. Coptis chinensis Franch. contains berberine, coptisine, tetrandrine, jatrorrhizine, methylcoptisine, magnolin, etc. [1].
9. The effect of1on chemical constituents showed that when cutting Rhizoma Coptidis, it should be done at low water temperature, and the soaking time in water should be reduced as much as possible, otherwise the drug effect would be lost [1]. At present, in practical application, Coptis chinensis is often mashed when it is used to avoid the loss of components during cutting [1].
After Rhizoma Coptidis was processed with wine, ginger juice and Evodia rutaecarpa juice, the contents of berberine, palmatine and jatrorrhizine had no obvious changes [1]. However, it has also been reported that the content of berberine in Rhizoma Coptidis decreased with the increase of processing temperature, but the dissolution rate of berberine in water can be improved by processing [1]. The dissolution rate of berberine in raw Rhizoma Coptidis is 58. 17%, and the dissolution rate of wine, ginger juice and Evodia rutaecarpa after processing is about 85%, which shows that processing can promote the dissolution rate of berberine in decoction [1]. However, some reports are different from the above conclusions. It is considered that the content of total alkaloids in the decoction of Evodia rutaecarpa is 8.68%, berberine is 19.35%, and palmatine is 3.45% lower than that in the decoction of Rhizoma Coptidis, which is consistent with the traditional understanding of reducing the coldness of Rhizoma Coptidis after the juice of Evodia rutaecarpa is processed. After Rhizoma Coptidis was processed by different methods, the content of berberine decreased in different degrees, especially the charcoal of Rhizoma Coptidis. However, after Huanglian was mixed with wine and dried, the content of berberine hydrochloride was higher than that of other processed products and raw products made by heating wine. The content of berberine hydrochloride in Rhizoma Coptidis fried with different amounts of white wine and yellow wine has little effect, but the content of water-soluble extract is obviously higher than that in raw products. The frying rate of trace elements Mn, Ca, Zn in wine-baked products is also significantly higher than that in raw products [1]. Therefore, it is inferred that the content and dissolution rate of alkaloids in Rhizoma Coptidis are affected by the amount of alcohol and heating temperature [1].
During the heating process, Rhizoma Coptidis can generate a red berberine alkaloid-Berberine [1]. Crude drug is produced when it is heated to 130℃, 1 hour, or 180℃ for 20 minutes, and its content increases with the increase of heating temperature and time, while berberine decreases correspondingly [1]. Heating can also change the structure of tetrandrine and jatrorrhizine [1]. It is suggested that the relationship between heating and quality change of Rhizoma Coptidis should be studied [1].
9.2 Studies on pharmacological effects show that berberine has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, with antipyretic, anti-inflammatory, anti-ulcer, cholagogic effects, platelet aggregation inhibition, blood sugar reduction and antiarrhythmic effects, and has protective effects on myocardial ischemia and myocardial infarction [1]. After processed with wine, ginger juice and Evodia rutaecarpa juice, Coptis chinensis still has antibacterial activity in different degrees, and all of them have unprecedented inhibitory effect on Pseudomonas aeruginosa [1]. In addition, the inhibitory effect of Rhizoma Coptidis processed with ginger juice on Proteus was enhanced, and it was better than other processed products [1].
Storage method of 10 Evodia rutaecarpa