1. Those who are allergic to any component of the vaccine or have had severe allergic reactions to vaccines in the past, such as acute allergic reactions, urticaria, skin eczema, dyspnea, angioedema or abdominal pain.

2. Those who have fever, suffer from acute diseases, serious chronic diseases, or are in the acute onset stage of chronic diseases.

3. Pregnant women and lactating women must have a childbirth plan within 3 months of vaccination.

4. Those who have a history or family history of convulsions, epilepsy, encephalopathy or mental illness; those who suffer from uncontrolled epilepsy and other progressive neurological diseases, and those who have a history of Guillain-Barré syndrome.

5. Have been diagnosed with congenital or acquired immune deficiency, HIV infection, lymphoma, leukemia or other autoimmune diseases.

6. Those who are known or suspected to have severe respiratory diseases, serious cardiovascular diseases, liver and kidney diseases, or malignant tumors.

7. Those who use immune modulators such as anti-tumor drugs.

8. Those with a history of COVID-19 infection.

9. Clinicians or vaccination staff believe that the person is not suitable for vaccination.