Three major differences between Sophora Tonkinensis and Sophora Tonkinensis
1. Efficacy difference
Sophora Tonkinensis: It has the effects of clearing away heat and toxic materials, relieving swelling and relieving sore throat. Indications: swollen throat, sore throat, throat wind, swollen gums, etc.
Rhizoma Menispermi: It has the effects of clearing away heat and toxic materials, expelling wind and relieving pain. Indications: sore throat, tonsillitis, rheumatalgia, numbness of limbs, enteritis and dysentery.
2. Toxicity difference
Sophora Tonkinensis: Modern research shows that matrine contained in Sophora Tonkinensis can act on the brain, cause spasm, and paralyze the diaphragm and respiratory muscle motor nerve endings. Mice were enema with 25g/kg decoction of Sophora Tonkinensis, and the results showed respiratory depression, convulsion, spasm and death.
Menispermum dauricum: Menispermum dauricum is the main component. The subacute toxicity test with Menispermum dauricum showed that the drug had no adverse effect on the heart for 18 days or 2-3 months at a dose of 4.8-6 mg, and the liver was damaged to varying degrees at a dose of more than 15 mg for 2-3 months, and the damage degree was aggravated with the increase of dose, resulting in mild damage, and less than 15 mg was harmful to the liver.
3: Character difference
Menispermum dauricum: it is the dried rhizome of Menispermaceae. Location: Northeast China, Hebei, Shandong, Shanxi and other places. Its rhizome is slender and cylindrical, with yellow-brown to dark-brown surface, many curved thin roots, and protruding root marks and longitudinal wrinkles can be seen. The skin is easy to peel off and tough and not easy to break. The shape of the decoction pieces is round and thick, with pale to light yellow section, light yellow wood, radial arrangement, pith in the center, brown to light brown around, and slightly bitter smell.
Sophora Tonkinensis is the dried root and rhizome of Sophora Vietnamese, a leguminous plant, mainly produced in Guangdong and Guangxi, also known as Sophora Tonkinensis. Broad bean root? . Its rhizome is irregular and nodular, and its rhizome is long and cylindrical, slightly curved, and often branches with different lengths. The surface is grayish brown to brownish brown, with longitudinal wrinkles and horizontal lenticels-like protrusions, which are hard and not easy to break. The characteristics of the decoction pieces are round-like slices, with light brown skin on the surface, light yellow wood, brown or brown around, hard texture, fishy smell of beans and extremely bitter taste.
Therefore, although both of them have the effects of clearing away heat and toxic materials, matrine, the main component contained in Sophora Tonkinensis, is more toxic than dauricine contained in Menispermum Menispermum. In the 21 edition of China Pharmacopoeia, the dosage of Menispermum dauricum is 3 ~ 9g, while that of Sophora Tonkinensis is 3 ~ 6g, the purpose of which is to prevent poisoning accidents. Therefore, whether it is the sales department or each medical unit, the pharmacopoeia should prevail, and the two drugs should be used separately and must not be mixed with each other.
efficacy and function of Sophora Tonkinensis
(1) Functions
Clearing away fire, detoxicating, reducing swelling and relieving pain. Treat carbuncle of larynx, laryngitis, laryngitis, gingival swelling and pain, dyspnea with heat cough, jaundice, dysentery, hemorrhoid disease, heat swelling, alopecia, scabies, snake, insect and dog bites.
"Kaibao Materia Medica": "The main solution to all kinds of drug toxicity, pain relief. "Eliminating sores, swelling, acute yellow fever and cough, and killing bugs."
The Classic of Materia Medica: "Contains to relieve sore throat."
clearing away heat and toxic materials, the original taste is sweet and bitter, and the gas is cold, as in "Ben Cao Jing Shu". Radix Sophorae Tonkinensis is sweet, so it harmonizes with poison, and cold, so it removes heat. Any poison must be hot and pungent, and if it gets cold-clearing gas and bitter taste, all the poisons will self-resolve, so it is the medicine for detoxification and heat clearing. ?
detumescence and pain relief "seeking truth from materia medica" says:? Radix Sophorae Tonkinensis is the first medicine for purging the heart and protecting the lung, reducing yin and meridian fire, and relieving swelling and carbuncle of throat. ? "materia medica huiyan" said:? Sophora Tonkinensis root, bitter and cold, has been ordered to descend, and it is good to get rid of lung and stomach stagnation. All sudden heat diseases, cool and detoxify, are all inappropriate. ?
(II) Pharmacological effects
1. Anti-inflammatory, antipyretic and antibacterial
Matrine, oxymatrine and sophocarpine have significant anti-inflammatory effects. Sophora flavescens has obvious inhibitory effects on the increase of capillary permeability in abdominal cavity of mice, foot swelling and cotton granuloma of rats.
Oxymatrine can significantly reduce the normal body temperature of rats and the fever of rabbits.
Sophora tonkinensis has certain antibacterial effect in vitro. Matrine has a significant inhibitory effect on a variety of bacteria. The decoction of Sophora Tonkinensis has a strong anti-coxsackie virus B5 effect. Radix Sophorae Tonkinensis has inhibitory effect on spirochetes and fungi.
2. Anti-cancer
Matrine has obvious inhibitory effects on sarcoma S18 and cervical cancer Ul4 in mice, and oxymatrine has obvious inhibitory effects on Sl8. The chemotherapy coefficient of oxymatrine is stronger than that of mitomycin. Lignin and sophocarpine also inhibited Sl8.
Oxymatrine can induce cytochrome P45 in mouse liver microsomes, improve its metabolic activation of cyclophosphamide, and make half dose of cyclophosphamide have the same anti-tumor effect as full dose.
3. Immunosuppression and regulation
Matrine, oxymatrine, sophocarpine and genistein all have immunosuppressive effects on mice. Matrine intravenous injection has obvious cytotoxic effect on macrophages, and can obviously reduce its effect of inhibiting the proliferation of P815 cells, reduce its phagocytosis, and obviously inhibit the proliferation of mouse spleen T cells and the production of IL-2. Higher dose subcutaneous injection of oxymatrine can inhibit the phagocytosis of peritoneal macrophages in mice.
Matrine, oxymatrine and sophocarpine can all inhibit tumor-associated immunity (TCI) and antibody production, and matrine has the strongest immunosuppressive effect.
It is also reported that oxymatrine has a two-way effect on T cells, B cells and cytokines in mice with different doses, and it has an inhibitory effect at a high concentration of lmg/ml, 1? 1-6 low concentration is the enhancement effect. It has also been reported that oral administration of Sophora Tonkinensis can improve the neutralizing activity of mouse Meth tumor cells and the levels of serum IgG and IgM.
Matrine has obvious whitening effect. It can obviously promote the increase of leukopenia in rabbits caused by X-ray and 6 Co-ray.
Efficacy and function of Menispermum Menispermum
1. Menispermum Menispermum has a good effect of clearing away heat and toxic materials, promoting diuresis and reducing swelling, and has a good therapeutic effect on sore throat. Menispermum Menispermum can be used for treating mumps or diarrhea, jaundice or rheumatic arthralgia, and for swelling and pain of hemorrhoids, esophageal cancer or gastric cancer. If you are unfortunately bitten by a snake or insect, you can also choose to use Rhizoma Menispermi for external application, and you can also treat spider injuries.
2. Rhizoma Menispermi can also be used to treat cough such as pneumonia and bronchitis, which is good for enteritis dysentery and tapeworm. Rhizoma Menispermi has a good anti-cancer effect. Especially in the treatment of esophageal cancer and gastric cancer, the effect is very good. Menispermum dauricum is also effective in treating cervicitis and stomatitis in women.
3. Rhizoma Menispermi has a good antiarrhythmic effect on cardiovascular system. Rhizoma Menispermi contains a substance called dauricine, which is a broad-spectrum antiarrhythmic substance, especially for ischemic arrhythmia.
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