In terms of ingredients: cheese slices are usually processed cheese in sliced form, which may contain other additives and preservatives. Cream cheese is a dairy product with cream as its main ingredient and usually contains only cream and a small amount of salt.

Texture: Sliced cheese usually has a harder texture and firmness that makes it suitable for melting, baking and sprinkling on food. Cream cheese, on the other hand, has a fine, soft texture and is usually used in mixes, spreads or as a topping for cakes and desserts. So cheese slices can replace cream cheese.