It is an immune-related systemic vasculitis nephritis. At present, the exact etiology and pathogenesis of the disease are still unclear. It is generally considered to be immune-related systemic vasculitis, which may be caused by immune complex containing IgA. The severity of renal involvement is an important factor affecting the prognosis. Generally speaking, Henoch-Schonlein purpura is a self-limiting process. The course of disease is 3 ~ 6 weeks for those without renal involvement, and 9 months ~ 6 years for those with renal involvement, depending on the severity of the disease. About 6% of chronic nephritis was delayed, and 1.5% entered renal insufficiency. Clinical manifestations of Henoch-Schonlein Purpura Nephritis: About 80% of Henoch-Schonlein Purpura Nephritis occurred within one month after the appearance of Henoch-Schonlein Purpura, mainly including edema, hypertension and urine changes. Edema is mostly mild, and urine changes are mainly hematuria and proteinuria, especially hematuria. Some cases can start with kidney disease, which is easy to be misdiagnosed because the systemic symptoms are not obvious. The clinical manifestations of henoch-schonlein purpura nephritis are different, edema and hypertension are not obvious, and only hematuria is observed under the microscope. Some sick children may start with acute nephritis syndrome, including gross hematuria, edema and hypertension. A few children showed secondary nephrotic syndrome, which showed obvious edema and massive proteinuria with hematuria. In addition, a few cases have rapid onset and progress, including early oliguria or anuria, obvious azotemia, and progressive increase of serum creatinine. Until renal insufficiency, or persistent chronic nephritis.