Goosebumps are characterized by roughness and cracking of the palms of the hands. At the beginning of the palm and fingers subcutaneous small pimples, itching, then herpes broken, iterative white skin, flaking, long time skin roughness and thickening; or even cracking pain, aggravated by winter, from the palm can be extended to all hands; further development can cause nail thickening, color gray and yellow and brittle, the course of the disease lingering. See the modern medicine of the hand chronic eczema, palm metatarsal keratosis and other diseases.