Sanhuang tablet is a cheap and commonly used Chinese patent medicine, which is composed of rhubarb, coptis root and scutellaria root. Traditionally, it is used for red face and dry mouth, aphtha and carbuncle, body heat and polydipsia, damp-heat jaundice, or hematemesis and epistaxis caused by excessive heat forcing blood. In recent years, through clinical practice, many new functions have been found.

1, hyperlipidemia: Sanhuang tablets 3-4 tablets each time (0.25g each, equivalent to 0.61g of crude drug), twice a day, 15 days is a course of treatment.

2, acute bacillary dysentery: take Sanhuang tablets orally, 4 tablets each time, 3 times a day. More than 5 days, less than 3 days to show good results. The medicine has inhibitory effect on Shigella dysenteriae and Escherichia coli. In the formula, rhubarb has a purgative effect and can also reduce the absorption of toxins in the intestine, so Sanhuang tablet has a good effect on dysentery.

3, acne: Sanhuang tablets take 3-4 tablets each time, 3 times a day. Three days is a course of treatment. Generally, after 3-5 courses of medication, the local redness and swelling can be eliminated, and the pain disappears. Avoid spicy, greasy and fried products during treatment.

4, suppurative otitis media: first dry the infected ear pus with a cotton swab, then rinse it with hydrogen peroxide, and then grind Sanhuang tablets into fine powder and blow it into the ear canal, once a day/kloc-0, for 3-7 days.

Special reminder is that pregnant women are forbidden to use Sanhuang tablets. TCM syndrome differentiation belongs to spleen and stomach deficiency and cold, which should also be avoided.

Sanhuang tablets

Pinyin name: Sanhuang Pian

English name:

Page number: 2000 Edition 1 -354

Prescription rhubarb 300g berberine hydrochloride 5g scutellaria baicalensis extract 2 1g (equivalent to baicalin 15g).

Prepare the above three herbs. The extract of Scutellaria baicalensis Georgi is prepared by decocting Scutellaria baicalensis Georgi in water for three times, the first time is 1.5 hours, and the second time is.

Each time 1 hour, the third time for 40 minutes, mixing decoctions, filtering, adding hydrochloric acid to the filtrate to adjust the PH value to 1 ~ 2, and standing for1hour.

Take the precipitate, wash it with water to adjust the PH value to 5 ~ 7, dry it, pulverize it into fine powder, and determine the content for later use. Take rhubarb 150g,

Pulverizing into fine powder, and sieving; Pulverizing the rest Radix et Rhizoma Rhei into coarse powder, extracting with 30% ethanol under reflux for three times, filtering, and combining filtering.

Recovering ethanol, concentrating under reduced pressure to obtain thick paste, and adding Radix et Rhizoma Rhei fine powder, berberine hydrochloride fine powder and Scutellariae Radix extract fine powder.

And an appropriate amount of auxiliary materials, uniformly mixing, granulating, drying, pressing into 1000 tablets, and sugar coating.

Characteristics This product is a sugar-coated tablet, which is brown after sugar-coated is removed. It tastes bitter and slightly astringent.

Identification (1) Take this product and observe it under the microscope: calcium oxalate clusters are mostly broken, with a diameter of 20 ~140μ m..

(2) Take 5 tablets of this product, remove the sugar coating, grind them, add 30ml of methanol, heat and reflux for 30 minutes, let them cool, and filter them.

The filtrate is used as the test solution. Another berberine hydrochloride reference substance was added with methanol to make a solution containing 0.2mg 1ml, which was used as the reference substance.

Reference solution. According to the thin layer chromatography (Appendix ⅵ b) test, absorb 2μl of the above two solutions, and point them at the same place respectively.

On a silica gel G thin layer plate with sodium carboxymethyl cellulose as adhesive, ethyl acetate-butanone-formic acid-water (10:7: 1

: 1) as developing agent, developing, taking out, drying, and viewing under ultraviolet lamp (365nm). In the chromatogram of the test sample, in comparison with the control,

At the corresponding position of the chromatogram, the same yellow fluorescent spots appear.

(3) Take 5ml of the test solution under [Identification ](2), evaporate to dryness, add water 15ml to the residue, stir to dissolve, filter, and filter.

Adjust the PH value of the solution to1~ 2 with dilute hydrochloric acid, extract with ethyl acetate twice, each time 10ml, combine the extractive solutions, and evaporate to dryness to obtain residue.

Add methanol 1ml to dissolve, and use it as test solution. Taking baicalin as reference substance, adding methanol to prepare a solution containing 1mg per 1ml,

As a reference solution. According to the thin layer chromatography (Appendix ⅵ b) test, absorb 5μl of each of the above two solutions, and point them at.

On the same silica gel G thin layer plate with sodium carboxymethyl cellulose as adhesive, ethyl acetate-butanone-formic acid-water (5: 3:1:

1) as developing agent, developing, taking out, drying, and spraying with 2% ferric chloride ethanol solution. In the chromatogram of the test sample, in comparison with the control,

At the corresponding position of the chromatogram, spots of the same color appear.

(4) Take 5ml of the test solution under [Identification ](2), evaporate it to dryness, add water 10ml to the residue to dissolve it, and then add hydrochloric acid 1ml.

Heating in a hot water bath for 30 minutes, immediately cooling, extracting with ether twice, each time 10ml, combining the ether extracts, and volatilizing.

Ethyl ether, the residue is dissolved by adding ethyl acetate 1ml, which is used as the test solution. Another rhubarb control medicinal material 1g was taken and paired by the same method.

According to the medicinal solution. Then take chrysophanol and emodin as reference substances, and add methanol to prepare a mixed solution containing 0.5mg per 1mg, respectively.

It is a reference solution. According to the thin layer chromatography (Appendix ⅵ b) test, absorb 5μl of each of the above three solutions, and point them at

On the same silica gel G thin layer plate with sodium carboxymethyl cellulose as adhesive, petroleum ether (30 ~ 60℃)-ethyl formate-formic acid was used.

(15:5: 1) as developing agent, developing, taking out, drying, and viewing under ultraviolet lamp (365nm). Test color

In the spectrum, the same five orange fluorescent main spots are displayed at the positions corresponding to the chromatogram of the reference medicinal materials, and the same five orange fluorescent main spots are displayed in the chromatogram of the reference medicinal materials.

At the corresponding position, the same orange-yellow fluorescent spots appear; After being smoked in ammonia vapor, the spots turn red when examined in sunlight.

Check the chromatogram of the sample under [Identification ](2), examine it under the ultraviolet lamp (365nm), and test it in

Above the spots of berberine hydrochloride, there shall be no persistent blue-purple fluorescent spots.

Others shall comply with the relevant provisions under tablets (Appendix I D).

The content was determined by high performance liquid chromatography (Appendix ⅵ d).

Octadecylsilane bonded silica gel was used as filler for chromatographic conditions and system applicability test. Methanol -0. 1% phosphoric acid solution

(85:15) is the mobile phase; The detection wavelength is 254nm. The theoretical plate number should be no less than 2000 calculated by emodin peak.

Preparation of reference solution: Accurately weigh appropriate amounts of emodin and chrysophanol reference materials respectively, and add anhydrous ethanol-ethyl acetate (

2:1) to prepare a mixed solution containing 0.0 1mg emodin and 0.025mg chrysophanol per 1ml.

Preparation of test solution Take 20 tablets of this product, remove the coating, weigh it accurately, grind it (pass through No.3 sieve), and weigh it accurately.

Appropriate amount (about equivalent to the weight of 1 tablet), put it in a conical bottle, add 25ml of ethanol accurately, plug it tightly, weigh it, and add it in a water bath.

Hot reflux 1 hr, cooling, supplementing the lost weight with ethanol, filtering, accurately measuring the continuous filtrate 10ml, placing in a flask, and taking a water bath.

Evaporating to dryness, adding 30% ethanol-hydrochloric acid (1 0:1) solution 15ml, heating in a water bath for hydrolysis1hr, immediately cooling, and using chloroform for strength.

Shake and extract for 4 days, each time 15ml, combine chloroform solutions, put them on a water bath to dry, and dissolve the residue with anhydrous ethanol-ethyl acetate (2:1).

Solution, transfer to a 25ml volumetric flask, dilute to scale, shake well, filter with a microporous membrane (0.45μm), and collect the filtrate.

The determination method accurately sucks 10μl of the reference solution and the test solution respectively, injects them into the liquid chromatograph, and determines to obtain the product.

Each tablet of this product contains rheum emodin (C 15H 10O5) and chrysophanol (C 15H 10O4), which shall not be less than1.55mg..

Function and indications: clearing away heat and toxic materials, purging fire and relaxing bowels. It can be used for treating excessive heat in triple energizer, red eyes, sore mouth and nose, and sore throat.

Gum bleeding, upset and thirsty, yellow urine and constipation; Acute gastroenteritis, dysentery.

Usage and dosage: Take orally, 4 tablets at a time, twice a day, and reduce it for children.

Pay attention to pregnant women with caution.

Storage is airtight.