The disease mostly occurs in piglets aged 10~30 days. The most common disease of suckling piglets is yellow and white scour of piglets, the pathogen of which is Escherichia coli, but there are obvious differences in clinical symptoms of yellow and white scour of piglets. Diarrhea of piglets is also called delayed colibacillosis. The incidence of piglets aged 10-20 days is high, mostly piglets aged 10-30 days, with low mortality but high incidence. Yellow diarrhea in piglets is also called early-onset colibacillosis. Piglets over one week old have fewer diseases, mostly at 1-3 days old, with high mortality and morbidity. Newborn piglets are sensitive to external environmental factors and their physical skills are not perfect. When the humidity is too high or the temperature is too low, piglets will get sick. E. coli will be carried by sows, and it will be discharged into the environment with feces. Fences, pens, sow body surfaces and other places will be contaminated by Escherichia coli. Piglets are exposed to too many bacteria, and when they reach a certain amount, they will get sick. Small amount of breast milk, poor quality and late supplementary feeding of piglets will all lead to protein deficiency and infection of piglets. How to prevent yellow and white dysentery in piglets? It is necessary to ensure the normal nutrition supply of sows, so as to ensure the supply of breast milk and the normal development of piglets. Secondly, piglets should eat enough colostrum after birth to improve passive immunity and reduce morbidity. Finally, we must do a good job in environmental sanitation. Sows should be thoroughly disinfected before entering the delivery room. Cleaning the breasts and hindquarters of sows with 0. 1% potassium permanganate solution before delivery, and scrubbing the breasts when sows eat colostrum after delivery can reduce the probability of piglets being exposed to Escherichia coli. For pig farms with high incidence, intramuscular immunization once every 20 days before delivery, or once every 30 days and 15 days before delivery can prevent yellow and white dysentery to some extent. Adding related drugs to the feed of sows from 7 days before delivery to 7 days after delivery can reduce the content of Escherichia coli in sows and reduce their Escherichia coli emissions. Inject relevant preventive drugs into 1 day-old piglets to prevent Escherichia coli from multiplying in piglets.