on

Safety

of

Medicines) advises patients who take warfarin not to use cranberries, because the natural ingredients of cranberries contain salicylic acid, which can induce warfarin-related bleeding. Nevertheless, in 2006-2008, several retrospective analysis and experimental studies failed to prove the above effect, and the results of the above studies did not find the interaction between warfarin and cranberry (250ml/ day) [3].

. A gene (VKORC 1,

CYP2C9) has been proved to increase the sensitivity of warfarin, and people who carry this gene may induce bleeding after taking cranberries [4].

Cranberry is widely eaten as food, and developed into health care products in Australia and the United States. However, at present, there is a lack of research on its side effects. It is generally believed that cranberries should not be eaten with aspirin at the same time because they contain salicylic acid. Because it contains more sugar, diabetics should use it with caution; Because cranberries significantly increase oxalic acid levels, kidney calculi patients should use them with caution; Pregnancy and lactation can be used, but not as a daily diet [5]

There is no evidence to prove that the contraindications of cranberry include gynecological diseases, andrology diseases, facial diseases, stroke, etc., and it is impossible to get reasoning from physiology and pharmacology.