yì mǔ cǎo
2 English Referenceherba leonuri [Landau Chinese-English Dictionary]
leonurus [朗道汉英字典]/>
Leonurus heterophyllus Sweet [朗道汉英字典]/>
Leonurus sibiricus L. [朗道汉英字典]/>
motherwort [朗道汉英字典]/>
herba leonuri [Xiangya Medical Dictionary]
leonuri,herba [Xiangya Medical Dictionary]
motherwort herb [Xiangya Medical Dictionary]
Leonurus heterophyllus [21st Century Bilingual Science and Technology Dictionary]
Herba Leonuri (拉) [Nomenclature Review Committee of Chinese Medicine. Chinese Medicine Nomenclature (2004)]
motherwort herb [Chinese Medicine Nomenclature Validation Committee. Nomenclature of Chinese Medicine (2004)]
3 National Essential DrugsNational Essential Drugs Retail Guide Price Information Related to Motherwort
Serial No. Essential DrugsCatalog Serial No. Name of the Drug Formulations Specifications Units Retail Guide Price Category Remarks 932 82 Motherwort Ointment Decoction 125g Bottle 7 Proprietary Chinese Medicines Part * 933 82 Motherwort Ointment Decoction 10g Bottle 0.68%. Ointment 10g bottle 0.68 PCM part 934 82 Motherwort Ointment Decoction 15g bottle 0.98 PCM part 935 82 Motherwort Ointment Decoction 60g bottle 3.5 PCM part 936 82 Motherwort Ointment Decoction 100g bottle 5.7 PCM part 937 82 Motherwort Ointment Decoction 120g bottle 6.7 PCM part 938 82 Motherwort Ointment Decoction 138g bottle 7.7 PCM part 938 82 Motherwort Ointment Decoction 128g bottle 7.7 PCM part 938 82 Motherwort Ointment Decoction 128g bottle 7.7 PCM part 938 82 Motherwort Ointment Decoction 125g bottle 7.7 PCM part Bottle 7.7 Proprietary Chinese Medicine Part 939 82 Motherwort Cream Decoction 140g Bottle 7.8 Proprietary Chinese Medicine Part 940 82 Motherwort Cream Decoction 150g Bottle 8.3 Proprietary Chinese Medicine Part 941 82 Motherwort Cream Decoction 180g Bottle 9.8 Proprietary Chinese Medicine Part 942 82 Motherwort Cream Decoction 200g Bottle 10.8 Proprietary Chinese Medicine Part 943 82 Motherwort Cream Decoction 250g Bottle 13.3 Proprietary Chinese Medicine Part 944 82 Motherwort Cream Decoction 300g Bottle 15.7 Proprietary Chinese Medicine Part 945 82 Motherwort Cream Decoction 350g Bottle 18.2 Proprietary Chinese Medicine Part 946 82 Motherwort Cream Decoction 380g Bottle 19.6 Proprietary Chinese Medicine Part 947 82 Motherwort Cream Decoction 400g Bottle 20.6 Proprietary Chinese Medicine Part 948 82 Motherwort Granules Pellet Dosage 15g Bag 1 Proprietary Chinese Medicine Part * 949 82 Motherwort Granules Granules 5g Bag 0.36 Proprietary Chinese Medicine Part 950 82 Motherwort Granules Granules 2g (Sugar Free) Bag 0.88 Proprietary Chinese Medicine Part 951 82 Motherwort Capsules Capsules 0.35g*36 capsules Box (Bottle) 26 Proprietary Chinese Medicine Part *△ 952 82 Motherwort Capsules Capsules 0.35g*12 capsules Box (Bottle) 9 Proprietary Chinese Medicine Part 953 82 Motherwort Capsules 0.35g*24 capsules Box (bottle) 17.6 Proprietary Chinese Medicines Part 954 82 Motherwort Capsules 0.35g*72 capsules Box (bottle) 50.7 Proprietary Chinese Medicines Part 955 82 Motherwort Capsules 0.36g*12 capsules Box (bottle) 13 Proprietary Chinese Medicines Part 956 82 Motherwort Capsules 0.36g*24 capsules Box (bottle) 26 Proprietary Chinese Medicines Part 957 82 Motherwort Capsules Capsules 0.36g*36 capsules Box (bottle) 39 Proprietary Chinese Medicines Part 958 82 Motherwort Tablets Tablets 15mg*48 tablets (film-coated) Box (bottle) 16.6 Proprietary Chinese Medicines Part *△ 959 82 Motherwort Tablets Tablets 15mg*24 tablets (sugar-coated) Box (bottle) 7.7 Proprietary Chinese Medicines Part 960 82 Motherwort Tablets Tablets 15mg*30 tablets (sugar-coated) Box (bottle) 30 Tablets (sugar-coated) Box (bottle) 9.6 Proprietary Chinese Medicine Part 961 82 Motherwort Tablets Tablets 15mg*36 Tablets (sugar-coated) Box (bottle) 11.4 Proprietary Chinese Medicine Part 962 82 Motherwort Tablets Tablets 15mg*48 Tablets (sugar-coated) Box (bottle) 15.1 Proprietary Chinese Medicine Part 963 82 Motherwort Tablets Tablets 15mg*24 Tablets (film-coated) Box (bottle) 8.5 Proprietary Chinese Medicine Part 964 82 Motherwort Tablets Tablet 15mg*30 Tablets (Film-coated) Box (Bottle) 10.6 Part of Proprietary Chinese Medicines 965 82 Motherwort Tablets Tablet 15mg*36 Tablets (Film-coated) Box (Bottle) 12.6 Part of Proprietary Chinese Medicines
Note:
1. The dosage form specifications marked with "*" in the Remarks column of the table are representative of the products.
2. The dosage form specifications marked with "△" in the remarks column of the table and other specifications of the same dosage form are temporary prices.
3. For dosage form specifications with dosage indicated in the Remarks column, the prices of other specifications in the dosage form are calculated based on the same dosage and in accordance with the "Pharmaceutical Differential Pricing Rules".
4. The "honey pill" labeled in the dosage form column of the table includes small honey pills and large honey pills.
4 OverviewMotherwort
Motherwort is the name of traditional Chinese medicine, which is derived from the Classic of Materia Medica. It is the fresh or dried above-ground part of Leonurus japonicus Houtt. of the family Labiatae[1].
The Pharmacopoeia of the People's Republic of China (2010 edition) contains pharmacopoeial standards for this herb.
5 Latin nameHerba Leonuri (la) (Nomenclature of Traditional Chinese Medicine (2004))
6 English namemotherwort herb (Nomenclature of Traditional Chinese Medicine (2004))
7 Alias of motherwortwild hemp, jiutahua, shanmai, and safflower ai.
Beneficial Motherwort Artemisia, Safflower Ailanthus, Kun Cao, Xiao Summer Grass, Sesame Trees, Bitter Dropping Grass, Four-pronged Grass, Turbinate Bone Grass, Fire Hovenia, and Wild Asparagus, etc.[2].
Beneficent motherwort, Cnidium monnieri, Beneficent motherwort, Quinquefoil, Saffron wormwood, Beneficent motherwort, and Bitterwort [3].
8 SourceBeneficial motherwort is the fresh or dried above-ground part of Leonurus japonicus Houtt. of the family Labiatae[1].
Motherwort is the whole herb of Leonurus heterophyllusSweet, family Labiatae[3].
9 Proto-phytomorphologyAnnual or biennial herb, 0.3-1.8 cm tall. stems square, with inverted white hairs. Rooted leaves suborbicular, leaf margins 5-9-lobed, long-petiolate; middle leaves palmately 3-parted, lateral lobes 1-2-lobed; leaves on inflorescences linear-lanceolate, entire or with a few teeth, smallest lobe more than 3mm wide. Verticillasters axillary, with 8-15 flowers, mostly distant and forming long spikes; bracteoles needle-shaped, shorter than calyx tube, finely hairy; calyx campanulate, outside hairy, 5-toothed, first 2 teeth connivent; corolla light red or purplish red, 2-lipped, with ring of hairs in corolla tube, hairs on outside of upper lip, entire, lower lip 3-lobed, middle lobe obcordate; stamens 4, dichotomous, filaments scurfy. Nutlets oblong-triangular, smooth. Flowering from June to September, fruiting from September to October.
Born on roadsides and wastelands.
10 OriginMotherwort is produced in most parts of the country[3].
11 Harvesting and processingSummer stems and leaves are lush, flowers are not yet in bloom when harvested, sun-dried, or cut into sections and dried.
12 Sexual flavor and attributionMotherwort is bitter, pungent and slightly cold in nature; it is attributed to the liver, pericardium and bladder meridians. (Chinese People's **** and National Pharmacopoeia (2010 edition))
Motherwort is pungent, slightly bitter, slightly cold in nature; it enters the liver, pericardium and kidney meridians[3].
13 Efficacy and Indications of MotherwortMotherwort has the efficacy of activating blood circulation and regulating menstruation, diuretic and eliminating swelling, and is used for menstrual disorders, dysmenorrhea, menstrual closure, dysmenorrhea, edema and urination, and edema in acute nephritis.
Motherwort has the efficacy of activating blood and regulating menstruation, diuretic and eliminating edema[3]:
Motherwort is used to treat menstrual disorders, dysmenorrhea, amenorrhea, disintegration, post-partum abdominal pain with stasis of blood, hemosiderosis, nephritis and edema, dysuria, blood in the urine and itching of the skin: decoction, 9~30g[3].
Motherwort treatment of sores, swelling and poison, bruises and stagnation: pounded compresses or powdered dressing [3].
14 The chemical composition of motherwortThe whole herb contains leonurine, stachydrine, rutinoside, fenugreek acid, and leonuridine, and also contains leonurine A, B, etc.; the flowers contain leonuridine.
The whole herb of motherwort contains leonuridine, salicin, pre-Hispanic chalcone, leonuridine diterpenes, benzoic acid, oleic acid, sterols, rutinosides, and a large amount of potassium chloride, etc.[3].
15 Pharmacological effects of motherwortAn aqueous decoction of the alkaloids or leaves of motherwort caused uterine contraction, similar to ergometrine, and an aqueous infusion intravenously induced a decrease in blood pressure, an increase in urine output, and an increase in coronary flow in animals, and prevented and treated experimental myocardial ischemia, microcirculatory disorders, and ischemic renal failure[3].
Motherwort has an inhibitory effect on platelet aggregation and inhibits coagulation and thrombosis[3].
Motherwort inhibits common pathogenic skin fungi in the test tube [3].
16 Motherwort preparationsMotherwort runny extract, motherwort cream
17 Motherwort poisoningMotherwort contains a variety of alkaloids such as motherwort alkaloids, epsilonine, epsilon-nine, and salicinine, as well as arginine and lauric acid [2]. Pharmacological effects include uterine excitation, antimyocardial ischemia, antithrombotic, antiplatelet aggregation, anti-atherosclerosis, anti-inflammatory, antispasmodic, improve microcirculation, diuretic, hemolytic, antibacterial, antifungal. [2]
17.1 Mechanisms of adverse reactionsThe toxic constituent alkaloids of motherwort have excitatory and then *** effects on the central nervous system, especially on the respiratory center. It can act on the smooth muscle of peripheral blood vessels to dilate small arteries, causing a drop in blood pressure. To the heart, a small dose makes its contraction enhanced, and a large dose makes it stop beating. The contraction of the uterus is similar to that of ergot. Arrow poison like effect on motor nerves. [2]
17.2 Symptoms of motherwort poisoningThe incubation period of motherwort poisoning is 4-6h, and the amount of poisoning is 90-150g. The manifestations are generalized weakness, numbness of the limbs, generalized soreness, chest tightness, severe sweating, drop in blood pressure, coldness of the limbs, irregular respiration, lumbar pain, hematuria, cyanosis of the lips and mouth, shock, respiratory paralysis. Miscarriage can occur in pregnant women, and postpartum poisoning can cause uterine hemorrhage. [2]
17.3 TreatmentThe main points of treatment for motherwort poisoning are[2]:
1. Early vomiting and gastric lavage should be induced, while 5% glucose saline is administered intravenously to promote the excretion of toxins and to maintain the water-electrolyte balance.
2. Symptomatic treatment: when the blood pressure drops, be cautious with blood pressure-raising drugs, available norepinephrine drip, to keep the blood pressure close to the normal level. If there is bleeding, hemostatic drugs can be given, and blood transfusion if necessary. If there is respiratory distress, oxygen and respiratory stimulants can be given.
18 Pharmacopoeia standard of Yimucao 18.1 NameYimucao
Yimucao
LEONURI HERBA
18.2 SourceThis product is the fresh or dried above-ground parts of the plant Leonurus japonicus Houtt. of the family Labiatae. Fresh products are harvested in spring from seedling stage to early summer before flowering; dried products are harvested in summer when the stems and leaves are lush and the flowers have not yet bloomed or at the beginning of blooming, and then dried in the sun, or cut into sections and dried in the sun.
18.3 Traits 18.3.1 Fresh motherwortYoung plants have no stems, and the basal leaves are rounded-cordate, 5-9-lobed, with 2-3 blunt teeth per lobe. Pre-flowering stems are square-cylindrical, much branched in the upper part, concave down into longitudinal grooves on all sides, 30-60 cm long, 0.2-0.5 cm in diameter; surface greenish; texture fresh, pithy in the middle of the section. Leaves decussate opposite, petiolate; leaf blade green, fresh and tender, rubbed with juice; lower stem leaves palmately 3-lobed, upper leaves pinnately parted or lobed into 3 pieces, lobes entire or with a few serrations. Gas slightly, taste slightly bitter.
18.3.2 Dried motherwortStem surface gray-green or yellow-green; body light, tough, pith in the middle of the section. Leaf blade gray-green, more wrinkled, broken, easy to fall off. Verticillasters axillary, small flowers lavender, calyx tubular, corolla 2-lipped. The cut section is about 2cm long.
18.4 Identification(1) Transverse section of the stem of this product: epidermal cells are covered with cuticle, with velvet hairs; glandular scales are 4, 6, or 8 cells in the head, and unicellular in the stipe; non-glandular hairs are 1 to 4 cells. Hypodermal thick horny cells are more numerous at the angles. Cortex of several rows of thin-walled cells; endodermis conspicuous. Mesostylar sheath fiber bundles microlignified. Phloem narrower. Xylem more developed at angles. Thin-walled cells of pith larger. Thin-walled cells contain fine calcium oxalate needle crystals and small square crystals. Fresh part of the cortex near the epidermis thin-walled cells contain chloroplasts.
(2) Take 10 ml of test solution under the heading of soda hydrochloride [content determination], evaporate, add 1 ml of anhydrous ethanol to the residue to dissolve, centrifuge, and take the supernatant as the test solution (the fresh product was crushed after drying, and then made by the same method). Take soda hydrochloride control product, add anhydrous ethanol to make a solution containing 1mg per 1ml, as the control solution. According to the thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb the above two solutions of 5 ~ 10μl, respectively, on the same silica gel G thin-layer plate, acetone anhydrous ethanol and hydrochloric acid (10:6:1) as the unfolding agent, unfolding, remove, drying, heated at 105 ℃ for 15 minutes, cooled, sprayed with dilute bismuth potassium iodide solution of ferric chloride solution (10:1) mixed solution until the color of the spots is clear. The spots showed clear color. In the chromatogram of the test product, in the corresponding position with the chromatogram of the control product, the same color spots.
18.5 Inspection 18.5.1 MoistureDried motherwort? Shall not exceed 13.0% (2010 version of the Pharmacopoeia a Appendix IX H first method).
18.5.2 Total ashDried motherwort? Shall not exceed 11.0% (2010 version of the Pharmacopoeia a Appendix IX K).
18.6 LeachateDried motherwort? According to the water-soluble leachate determination method (2010 version of the Pharmacopoeia, Appendix X A) under the item of hot immersion method, shall not be less than 15.0%.
18.7 Content determinationDried motherwort
Alkaloid hydrochloride
Determined by high performance liquid chromatography (2010 version of the Pharmacopoeia, Appendix VI D).
Chromatographic conditions and system suitability test? Propylamide bonded silica gel was used as filler; acetonitrile 0.2% glacial acetic acid solution (80:20) was used as mobile phase; and detection was performed by evaporative light scattering detector. The theoretical plate count should be not less than 6000 based on the peak of saline hydrochloride.
Preparation of control solution? Take appropriate amount of control product of saline hydrochloride, weigh it precisely, add 70% ethanol to make a solution containing 0.5mg per 1ml, that is to say, it is obtained.
Preparation of test solution? Take the product powder (through the third sieve) about 1g, precision weighing, placed in a stoppered conical flask, precision addition of 70% ethanol 25ml, weighing, heating reflux for 2 hours, cooled, and then weighing, 70% ethanol to make up for the loss of weight, shaking, filtration, and take the filtrate, that is, obtained.
Determination method, respectively, precise suction of the control solution 5μl, 10μl, test solution 10-20μ1, injected into the liquid chromatograph, measurement, with external standard two-point method of logarithmic equation, that is, obtained.
This product is calculated according to the dry product, containing saline hydrochloride (C7H13NO2?HCl) shall not be less than 0.50%.
18.7.1 Alkaloid hydrochlorideDetermined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI B).
Chromatographic conditions and system suitability test? The mobile phase was 0.1% phosphoric acid solution (24:76) with 0.4% sodium octanesulfonate in acetonitrile as filler; the detection wavelength was 277 nm; the theoretical plate count should be not less than 6000 according to the peak of saline hydrochloride.
Preparation of the control solution: Take the appropriate amount of the control product of saline hydrochloride, weigh it precisely, and make a solution of 30 μg of saline hydrochloride per 1 m1 by adding 70% ethanol. Add 70% ethanol to make a solution containing 30μg per 1m1, it is obtained.
Determination method: Take 10μl each of the control solution and the test solution under the item of Hydrochloride [Content Determination], inject into the liquid chromatograph, and then determine, it is obtained.
This product contains not less than 0.050% of epsilonine hydrochloride (C14H21O5N3?HCl) calculated as dry product.
18.8 Motherwort Drinking Tablets 18.8.1 Concoction 18.8.1.1 Fresh motherwortRemove impurities and wash quickly.
18.8.1.2 Dried motherwortRemove impurities, wash quickly, moisten slightly, cut into pieces and dry.
The product is in irregular segments. Stem square, four sides concave into longitudinal grooves, gray-green or yellow-green. White pith in the middle of the cut surface. Leaf blade gray-green, much wrinkled, broken. Verticillasters axillary, flowers yellowish brown, calyx tubular, corolla bilabiate. Gas slightly, taste slightly bitter.
18.8.1.2.1 LeachateSame as the herb, not less than 12.0%.
18.8.1.2.2 Determination of contentThe same herbs, containing not less than 0.40% of Silymarinine Hydrochloride (C7H13NO2?HCl) and not less than 0.040% of Motherwort Hydrochloride (C14H21O5N3?HCl).
18.8.1.2.3 InspectionSame as herbs.
18.8.2 Flavor and attributionBitter, pungent, slightly cold. Attributed to the liver, pericardium and bladder meridians.
18.8.3 Functions and IndicationsPromoting blood circulation and regulating menstruation, diuretic and subduing swelling, clearing heat and removing toxins. It is used for menstrual disorders, dysmenorrhea and menstrual closure, incomplete discharge, edema and urination, sores and swollen toxins.
18.8.4 Usage and Dosage9-30g; fresh 12-40g.
18.8.5 CautionUse with caution in pregnancy.
18.8.6 StorageDry motherwort in a dry place; fresh motherwort in a cool and moist place.
18.9 OriginChinese People's Pharmacopoeia 2010 Edition
19 Motherwort Pharmacopoeia 19.1 IndicationsClinically used for: 1. Post-partum uterine insufficiency, uterine bleeding. 2. 2. Stopping bleeding, regulating menstruation and treating dysmenorrhea.
19.2 Dosage and Administration1. Intramuscular injection: 20-40mg once, 1 or 2 times daily. 2. Cervical and uterine wall injection: 40mg each time. 3. In case of hemorrhage in obstetrics and gynecology, intramuscular injection of 160-240mg.
19.3 PrecautionsProhibited in pregnant women before the placenta is discharged.
19.4 Specifications1. Injection: 20mg (1ml) per injection. 2. Tablets: 0.5g per tablet, equivalent to 1.67g of motherwort.
20