Traits The product is an irregular nodular fist-shaped mass, 2-7cm in diameter, with a yellowish-brown surface, rough and wrinkled, with most parallel elevated whorls, the top of which has a concave rounded stem scar, and there are most small verrucose root scars on the lower side and whorls. The texture is solid, not easy to break, the section is yellowish white or grayish yellow, scattered with yellowish brown oil chamber, the formation layer is undulating ring. Gas strong aroma, taste bitter, pungent. Slightly numb tongue sensation, slightly sweet.
Identification
(1) Transverse section: the cork layer is more than 10 rows of cells. Cortex is narrow, scattered root traces of vascular bundles, the formation of the layer is obvious. The phloem is broad, and the formation layer is annular undulate or irregular polygonal. Xylem ducts are polygonal or orbicular, mostly uniseriate or arranged in a "V" shape, occasionally with wood fiber bundles. The pith is large. Thin-walled tissues scattered with most of the oil chamber, orbicular, ellipsoid or irregular shape, light yellowish brown, close to the formation of the oil chamber of the layer is small, outwardly asymptotic; thin-walled cells are rich in starch granules, and some of the thin-walled cells contain calcium oxalate crystals, in the form of rounded masses or clusters of crystals. The powder is light yellowish brown or grayish brown. The starch granules are more, single granules are ellipsoid, oblong, orbicular, ovoid or reniform, with a diameter of 5-16μm and a length of about 21μm, umbilical dot-dot, long slit, or herringbone; occasional compound granules are seen, consisting of two to four sub-granules. Calcium oxalate crystals existed in the thin-walled cells, in the form of rounded clusters or clusters of crystals, with a diameter of 10-25 μm. cork cells were dark yellowish brown, often overlapping in multiple layers, with a polygonal surface view and thin walls. The oil cells were mostly broken, and occasionally fragments of oil cells were seen, and the secretory cells were thin-walled and contained more oil droplets. The conduit is mainly a threaded conduit, there are also reticulated and trapezoidal conduit, diameter 14 ~ 50μm, some of the threaded conduit thickened wall interconnected, like a reticulated threaded conduit.
(2) Take 1g of the powder, add petroleum ether (30-60 ℃) 5ml, placed 10 hours, shaking, standing, take 1ml of the supernatant, evaporate dry, the residue with methanol 1ml to dissolve, then add 2% 3,5-dinitrobenzoic acid methanol solution 2-3 drops with methanol saturated potassium hydroxide solution 2 drops, showing a reddish purple color.
(3) Take 1g of this product powder, add 20ml of ethanol, heating reflux for 1 hour, filtration, filtrate evaporation, residue with ethyl acetate 2ml to dissolve, as a test solution. Take 1g of Chuanxiong Ligusticum control herb, and make control herb solution by the same method. According to the thin layer chromatography (Appendix VI B) test, absorb the above two solutions of 1 ~ 2μl, respectively, point on the same silica gel G thin layer plate, hexane - ethyl acetate (9:1) as an unfolding agent, unfolding, remove, drying, placed in the ultraviolet lamp (365nm) under the examination. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the fluorescent spots of the same color were shown.
Check Total ash shall not exceed 6.0% (Appendix IX K).
Concoction Remove impurities, separate the size, slightly soaked, washed, moistened, thinly sliced and dried.
The properties and attributes of the herb are: acrid, warm. Attributes to the liver, gallbladder and pericardium meridians. This species is a poisonous plant included in the Chinese plant atlas database, and its toxicity is that mice injected intraperitoneally with the volatile oil of the rhizomes with LD50 of 328mg/kg, showed reduced activity, ****ji disorder, and the disappearance of the reflex of turning over the right side, and died in 4-5 hours; the weakly alkaline component of the fraction had similar symptoms, and another ÷strongly alkaline component had paroxysmal convulsions, and vasoconstriction, dyspnea; the lethal dose of the ethanol extract administered intraperitoneally to mice was equivalent to 14-23.8 g/kg of rhizome. Volatile oil to dogs injected intravenously, salivation, vomiting, defecation, hind limb weakness, tremors, spasms, paralysis, the dose of more than 150mg / kg immediately died.
Functions and Indications Promote blood circulation, expel wind and relieve pain. It is used to pacify the nerves, correct headache, abdominal pain in the abdomen and obstruction, stabbing pain in the chest and hypochondrium, swelling and pain in falling and thumping, headache, rheumatism and paralysis.
Use and dosage 3~9g.
Storage In a cool and dry place, prevent moth.
Ligusticum chuanxiong
The flavor is pungent, warm.
①Benjing: "Pungent flavor, warm."
② "Wu Pu Ben Cao": "Huang Di, Qibo, Lei Gong: pungent, non-toxic, fragrant. Magpie: sour, non-toxic. Li: raw and warm, cooked and cold."
③Tang Ben Cao: "Taste bitter and pungent."
④Ben Cao Zheng: "Tastes pungent and slightly sweet, and is warm."
Attributed to the liver and gallbladder meridians.
①Tang Liquid Materia Medica: "Entering the syncopal meridian of the hands and feet and the Shaoyang meridian."
②The Drugs of the Meaning: "Entering the liver, spleen and Sanjiao meridians."
Contraindications
Contraindications: wind-cold headache, wind-heat headache, migraine, vascular-neurological headache should be eaten.
Contraindications: hypertensive headache, brain tumor headache, liver fire headache, as well as those who have a deficiency of yin and fire are contraindicated.
Functions and Indications:
It is used to promote the flow of qi and open up depression, to promote wind and dry dampness, and to promote blood circulation and relieve pain. The treatment of wind cold headache dizziness, dystocia, abdominal pain, cold paralysis contracture, menstrual closure, difficult to give birth, postpartum stasis block pain, carbuncle sores and ulcers. It is used for menstrual disorders, menstrual closure and dysmenorrhea, abdominal pain in the abdomen and abdomen, stabbing pain in the chest and hypochondrium, swelling and pain, headache, and rheumatism paralysis.
①Benjing: "Mainly used for stroke into the brain headache, cold paralysis, contracture of tendons and slow urgency, gold wounds, women's blood closure and childlessness."
② "Other Records": "In addition to the cold movement in the brain, the face of the wind upstream to come, eye tears, more snot and spit, suddenly like a drunkenness, all the cold gas, heart and abdominal pain in the middle of the evil, the stroke of the rapid swelling and pain, coercive wind pain, warming in the internal cold."
3 Tao Hongjing: "Those who bleed at the root of the teeth, contain more than a disease."
④The Treatise on Medicinal Properties: "Treating weakness of the waist and feet, hemiplegia, the Lord's uterus does not come out, and treating cold pain in the abdomen."
⑤ Rihua Zi Materia Medica: "Treating all winds, all qi, all labor damage, all blood, tonifying the five labors, strengthening the muscles and bones, regulating the veins, breaking the knot of the disease of persistent blood, nourishing the new blood, growing the flesh, nasal flooding, vomiting and drowning blood, hemorrhoids and fistulas, cerebral carbuncle and hair on the back, scrofula and galls, sores and scabies, and draining the pus and eliminating the stasis of blood."
6 Medical Qiyuan: "Nourishing blood, treating blood deficiency headache."
⑦ Wang Hao Gu: "Searching liver qi, tonifying liver blood, moistening liver dryness, and tonifying wind deficiency."
8 "Compendium": "drying dampness, stopping diarrhea and dysentery, moving qi to open depression."
Use and dosage for internal use: decoction, 1 ~ 2 money; or into the pill, bulk, external use: powdered sprinkles or dressing.
Contraindications and contraindications Yin deficiency and fire exuberance, the upper and lower parts of the body are deficient and those with weak qi should not take it.
①The Materia Medica Collected Notes: "Angelica dahurica for the make. Wicked yellow dock."
② "Pinhui Jingyao": "Taken for a long time, it will dissipate the true qi."
③ "Materia Medica": "Wicked astragalus, mountain juju, wolf venom. Fear of saltpeter, talcum, Huanglian. Anti-veratrum."
4 《Ben Cao Jing Shu》："Where the patient's top is full and the bottom is weak, the fire of emptiness is inflamed, vomiting and coughing, self-sweating, easy sweating, night sweating, dry throat and mouth, fever for thirst and irritability, the law and contraindicated."
⑤ The Materia Medica from the New: "It is not suitable for use in qi ascension and phlegm asthma."
6 "Getting and Matching the Materia Medica": "It is forbidden to be used for fire drama in the center of fullness, deficiency of the spleen with little food, and fire depression and headache."
Selected prescription ① treatment of all wind up attack, head and eyes, headache, headache, nasal congestion, nasal congestion, heavy voice, wind and strong heat, limb pain, muscle writhing, diaphragm heat and phlegm bloom, women's blood and wind attack propulsion, pain in the solar plexus, and the sense of the wind: mint leaves (not see the fire) eight taels, Ligusticum chuanxiong, thorn mustard (stalks) four taels each, Xiang Fu Solanum (fried) eight taels (not this book for the Xin Xin to go to the reed one or two), Fangfeng (to go to the reed) a two and a half, dahuric dahurica, Qianghao, licorice (糽窛), dahurica, Qianghao, Ganqiao, and other medicines. (爁) each two; the above medicine for the fine powder, each serving one money, after eating tea under the clear, often served head and eyes clear. ("Bureau Square" Rhizoma Chuanxiong Tea Mixing San)
② treatment of migraine headache: jingxiong fine file, wine soaked. ("Doumen Fang")
3 ③ treatment of the first wind spinning dizziness, dizziness, external integration of yang qi, wind and cold, stomach phlegm, partial headache, body constraints: Chuanxiong a catty, four two days of hemp. The above for the end, refined honey for pills, each two for ten pills. Take one pill per serving, chew carefully, and drink tea and wine after eating. ("Xuan Ming Lun Fang" Chuanxiong pill)
4 treatment of wind-heat headache: Chuanxiong one money, tea two money. Water one bell, decoction five minutes, hot before eating. ("Simple Single Formula")
5 treatment of abdominal pain in pregnancy (cell blockage): rhizoma rhizoma rhizoma rhizoma two taels, two taels of Colla Corii Asini, two taels of licorice, three taels of mugwort, three taels of angelica, four taels of peonies, six taels of dried dihuang. The right seven flavors with five liters of water, three liters of wine and boil, take three liters, remove the dregs, the gelatin to eliminate, take a liter of warm service, three times a day, not disease, more. ("The Golden Chamber" gum ai soup)
6 treatment of women pregnant five or seven months, due to things to build a knock on the tire, or the child died in the abdomen, the evil dew under the pain more than the mouth to silence, with this medicine to explore, if not loss of the pain stops, the child and the mother are at peace, if the tire is damaged immediately under: Angelica sinensis six taels (washed, removed, cut, roasted, scales), chuanxiong rhizoma rhizoma four taels (washed). On the coarse powder, each serving two money, a small cup of water, decoction to make the sobbing dry, a large cup of wine, stop a boil, remove the residue, warm service, silence of the mouth to instill, such as people traveling five, seven miles and then enter, but three services will be born. ("This formula" Buddha's hand song)
7 treatment of postpartum hemorrhagic: Angelica sinensis one or two, Chuanxiong five money, Jinghao Sui (fried black) two money. Water decoction. ("Wonderful Fang class editing")
8 treatment of post-partum pain in the heart and abdomen: chuanxiong (washing, filing), cinnamon heart (not see the fire, filing), wood (filing, Huai dry), angelica (remove the rutabaga, washing, filing, baking), peach kernel (peeled, pointed and double kernel, fried yellow) each one or two. On the fine powder. Each serving of one money, hot wine mix down, if you do not want to drink wine, that is, a lamp with water, medicine two money, decoction to seven minutes, with heat service. ("Health family treasure formula" Chuanxiong loose)
9 treatment of new birth block pain: angelica eight money, Chuanxiong three money, peach kernel 14 (peeled, pointed, research), black ginger five points, five points of roasted grass. With yellow wine, child's stool, each half of the decoction. ("Fu Qingzhu men and women's science" biochemical soup)
⑩ treatment of pediatric brain fever, good closed eyes, sun pain or eye red and swollen: chuanxiong, mint, Park Nitrogen two money, for the end, to a small amount of blowing in the nose. (The whole young heart Jian)
Clinical application of the treatment of angina pectoris
Take chuanxiong, saffron equal parts, made into tablets (each 12 tablets containing chuanxiong, safflower raw medicine 5 money each), each time 4 tablets, 3 times a day. 4 to 6 weeks for a course of treatment. Treatment of 84 cases (including 10 cases throughout the addition of Pueraria lobata tablets, 3 times a day, 20 mg each time; 2 cases in the 2 weeks of medication began to take milk did not take tablets), the results of the apparent effect of 9 cases, 57 cases of improvement, the basic ineffectiveness of 17 cases, aggravation of 1 case. It was observed that there was no obvious relationship between the severity of the disease and the efficacy; the efficacy of those who took Pueraria Mirifica and milky way tablets was not improved; the effect of the drug on the lipid profile was not significant. 60 cases of patients who took nitroglycerin were discontinued in 20 cases and the dosage was reduced in 15 cases in the course of the treatment, and electrocardiograms in some of the cases showed an improvement.
Pharmacological studies
* Vasodilatation
Chuanxiongxiongzine
①Relieves spasm of vascular smooth muscle (aortic strips) (induced by epinephrine, potassium chloride).
② Dilates coronary vessels and increases coronary blood flow. Counteracting myocardial ischemia and hypoxia caused by pituitary posterior lobe hormone. Reduce the degree of myocardial infarction lesions caused by ligation of coronary arteries.
③Dilating cerebral blood vessels Easy to cross the blood-brain barrier, more distribution in the brain; inhibit platelet aggregation; improve microcirculation.
Ferulic acid
①Increase coronary flow.
②Alpha receptor blockade, inhibit aortic constriction.
* Antithrombotic
Chuanxiong rhizome, compound coronary heart II formula: in vitro anti-thrombotic (thrombus length ↓ , thrombus dry and wet weight ↓).
Chuanxiongxiong zhen Increase cAMP content in platelets, reduce TXA2 activity; reduce platelet surface activity, inhibit platelet aggregation, depolymerize aggregated platelets.
Sodium ferulate TXA2 synthase inhibitor , inhibit platelet aggregation.
* Antispasmodic
Ligustrolactone - tracheal smooth muscle spasms;
Ferulic acid, Chuanxiongzine - uterine smooth muscle spasms;
Aqueous or alcoholic extracts - - small intestine and uterus.
Formulas
Name of formula: Ichi-San
Source of the prescription: Volume 17 of Medical Notes and Classes.
Composition: Angelica sinensis, Rhizoma Ligustici Chuanxiong, etc. (all washed in wine, fried), 5 slices of ginger.
Attention: Postpartum headache due to blood deficiency.
Use and dosage: Roasted, decoction.
Formula Name: One Twist of Gold San
Source: Imperial Medicinal Household Formulas, Volume IX.
Composition: Scorpion tip 2 qian, Rhizoma Ligustici Chuanxiong 1 tael, Sinapis Sinensis 1/2 tael, Angelica dahurica 1/2 tael.
Treatment: Toothache.
Preparation: Finely powdered.
Use and dosage: each take a little, with a finger dipped in the medicine and rub the toothache, spit Jin, accidentally swallowed may wish, not to be detained
These are the main ingredients of the medicine, but also the main ingredient of the medicine.