Louisville is the largest city in Kentucky, with an area of 65,438+0,032 square kilometers and a population of 700,000 (2005). It is located in the north-central part of Kentucky, just across the river from Indiana, and is a major port city on the south bank of the Ohio River. In the early economic development, Louisville mainly focused on shipping and freight. Recently, Louisville has become one of the major health care centers in the United States, mainly focusing on cardiology, hand surgery and. Louisville has universities such as the University of Louisville and Spalding University, and has the largest health insurance company in the United States. The city was founded by George Clark in 1778 and was named after French king Louis XVI. Louisville is famous for winning the Kentucky Derby for the first time.