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Diabetic nephropathy causes

1, heredity is also the cause of diabetic nephropathy.

Diabetic nephropathy can also occur in some patients with good long-term glycemic control. Glucose transporter protein is the main glucose transporter on the glomerular plasma cells. Recently, it has been found that differences in the expression and regulation of GLUT1 in glomerulocytes among diabetic patients may be one of the factors that predispose some patients to kidney damage. Moreover, the occurrence of diabetic nephropathy also shows a family aggregation phenomenon, in some diabetic patients with a family history of hypertension, the incidence of diabetic nephropathy is significantly higher than that of patients without a family history of hypertension.

Diabetic nephropathy is closely related to hyperglycemia, and poor glycemic control can accelerate the development of diabetic nephropathy, while good glycemic control can significantly delay its development. High blood glucose and increased production of glycosylated end products cause proliferation of mesangial cells, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening, etc.

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Diabetic nephropathy is closely related to hyperglycemia.

4. Due to abnormal renal hemodynamics

In diabetic nephropathy, it plays a key role, and may even be the initiating factor.

Diabetic nephropathy treatment

1, diabetic nephropathy oral hypoglycemic drug treatment

Glyburide (ugglutide), gliclazide (Damicam) active metabolites are mainly excreted by the kidneys. When renal function is impaired, it is easy to cause hypoglycemia, and should not be used. Glipizide (Glucophage) is mainly metabolized in the liver and only about 5% is excreted by the kidneys, so it is safer to use in renal insufficiency and can be used in a wide range of dosages, so it can be used as the first choice for patients with diabetic nephropathy. Some of the metabolites of glipizide (mepivoxil) are excreted by the kidneys, but the activity is weak, not easy to cause hypoglycemic reactions, and is safer.

2, control blood pressure, avoid the occurrence of hypertension

Hypertension is the main factor in the occurrence and development of renal function damage in renal patients, and it is a controllable factor. It is also true for diabetic nephropathy. Hypertension plays an important role in the development of diabetic nephropathy, therefore, controlling hypertension is the key to slow down the development of diabetic nephropathy. The first step to control hypertension is to limit the patient's sodium intake, at the same time, no smoking, alcohol cessation, weight loss, appropriate exercise, which is the basis of treatment.