Extended data:
Objective: To verify the osteogenic effect of a collagen scaffold material from Basha fish skin as a barrier membrane in Guided Bone Regeneration,GBR) of rabbit skull.
Methods: Two New Zealand white rabbits 12 were selected, and one defect was established on the left side and two defects were established on the right side of the sagittal suture of the cranium. The defects were round, with a diameter of 8mm, and there were 36 bone defects. Then they were randomly divided into two groups according to the observation time: 8 weeks and 12 weeks, and each group was randomly divided into three subgroups (n = 4).
In group A, only Bio-Oss bone powder was implanted in the defect, and in group B, Bio-oss bone powder and collagen scaffold material of Basha fish skin were implanted. Group c was implanted with Bio-oss bone powder and +Bio-Gide collagen membrane. The rabbits in the corresponding groups were killed at 8 weeks and 12 weeks after operation, and the bone tissue regeneration in the bone defect areas was quantitatively analyzed.
Results: Collagen scaffold can play the role of barrier membrane in GBR technology, and guide and promote the regeneration of rabbit skull tissue. Compared with Group C, there was no significant difference in osteogenesis effect at 8 weeks (P> 0.05)。 At 12 weeks, the effect of C on bone formation was slightly higher than that of Group B (P <: 0.05)； However, the osteogenic effect of group A at 8 weeks and 12 weeks was significantly lower than that of groups B and C (P < 0.05)。
Conclusion: Skin collagen scaffold, as a barrier membrane, plays a role in guiding bone regeneration in rabbit skull defect repair.
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