The role of progesterone injection in pregnant women
Progesterone is a natural progestin secreted by corpus luteum of ovary, which has a significant effect on endometrial morphology stimulated by estrogen in vivo and is necessary to maintain pregnancy. Clinically, it is often used for amenorrhea or amenorrhea reactive eruption caused by threatened abortion, habitual abortion, endometriosis, functional uterine bleeding, dysmenorrhea and ovarian dysfunction. It can also be administered vaginally instead of orally, especially for patients with liver disease.
Progesterone is a synthetic progesterone, which is generally used for threatened abortion or habitual abortion, functional amenorrhea or uterine bleeding, dysmenorrhea, endometrial adenocarcinoma, endometriosis and so on. If used in multiple doses, it will have a lasting contraceptive effect. Moreover, for the shedding caused by endometrial factors without estrogen and progesterone, estrogen and progesterone are gradually supplemented by artificial methods. Especially progesterone. This can ensure the continuous thickening of the endometrium, make the endometrium firmly attached to the uterine wall, and make the fertilized egg have a good implantation space. It can also delay menstruation.
What is progesterone?
Andromeda progesterone is also known as medroxyprogesterone acetate. Progesterone is a natural progesterone secreted by corpus luteum of ovary, which has significant morphological effect on endometrium stimulated by estrogen in vivo. It is necessary to maintain pregnancy and is mainly used for fetal protection and treatment.
Guidance: Progesterone is a drug for promoting pregnancy, and its activity is 20 ~ 30 times that of progesterone when injected subcutaneously. Intramuscular injection has a long-term effect and can be used to treat functional bleeding, amenorrhea and endometriosis caused by hormone imbalance.
Usage and dosage:
1, threatened abortion: oral 1 time 4 ~ 8 mg, 1 day 2 ~ 3 times. Habitual abortion, daily 10mg for the first 3 months, 20mg daily after 4 ~ 4.5 months, and finally stop taking the drug.
2. Dysmenorrhea: From the 6th day of menstrual cycle, take/kloc-0 orally, 2 ~ 4 mg each time, for 20 days; Or take it three times from the first 1 day of menstruation, and take it for three days continuously.
3. Functional amenorrhea: take 4-8 mg daily for 5- 10 days.
Side effects of progesterone
First of all, patients with thrombophlebitis, thromboembolic diseases, severe liver insufficiency, hypercalcemia, overdue abortion, uterine bleeding, pregnancy or allergy to this product are prohibited from using this product.
Its side effects are:
1. Similar to other progesterone drugs, breast pain, galactorrhea, amenorrhea, cervical erosion or changes in cervical secretion, and feminization of male breasts may occur.
Mental aspects: nervousness, insomnia, lethargy, fatigue, dizziness.
3. Skin and mucous membrane: allergic reactions have been reported, including itching, measles, angioneurotic edema, systemic rash and no defensive reaction, and a few cases have reported acne, baldness or hirsutism.
4, gastrointestinal tract: nausea, indigestion, especially in large doses.
5, the body: sometimes it will cause breast pain and flatulence.
6, may also produce similar adrenal cortisol reaction and hypercalcemia reaction, occasionally there are reports of obstructive jaundice.
Precautions of progesterone in angong
1. This drug must be used under the guidance of an experienced clinician. Once the symptoms of thromboembolism, such as migraine, decreased vision and diplopia, are caused by drugs enhancing the coagulation mechanism, the drug should be stopped immediately.
2. Some women will have irregular bleeding and other reactions. In case of bleeding, ethinylestradiol 0.05 ~ 0. 1 mg can be added according to the amount of bleeding, and the bleeding can be stopped after 3 days. Use with caution in patients with liver disease and nephritis.
3, there is a certain androgen effect, and long-term use during pregnancy can lead to masculinization of female fetuses.
4. Thromboembolic diseases, hepatic and renal insufficiency, breast tumors and abortion are prohibited.
5. During continuous high-dose MPA treatment, attention should be paid to hypertension, water and sodium retention, hypercalcemia, etc. If these symptoms appear, it is necessary to adjust the medication.
6. This product may cause a certain degree of body fluid retention. Patients with epilepsy, migraine, asthma, cardiac insufficiency or renal insufficiency should observe carefully when using this product.
7. Patients with a history of depression need careful observation, and patients with severe recurrent depression need to stop taking drugs. When some patients use progesterone, their tolerance to glucose decreases, so diabetic patients should use it with caution.