The etiology of urticaria is not clear at present, but it is found to be related to factors such as allergies, infections and autoimmune diseases. When patients come to see a doctor, they often describe that rashes and itching will appear every night and disappear automatically in the morning. This situation is considered to be caused by the decline of autoimmune, which is more common in lactating women and patients with chronic diseases such as hyperthyroidism, anemia and diabetes. Breast-feeding women stop breastfeeding, and after a period of recovery, urticaria will improve on its own; Patients with chronic diseases should treat the primary disease first, and urticaria will no longer appear after the primary disease improves. If the patient does not find the disease, immunomodulatory drugs, such as spleen aminopeptide freeze-dried powder, transfer factor oral liquid, Huaiqihuang granules, etc. , it will gradually reduce the number of rashes in the night of 1-3 months until it disappears.