Try to rule out suspicious reasons. Besides antihistamines, 6- aminocaproic acid, vitamin K, vitamin E, vitamin B 12, histamine globulin, transfer factor and antibiotics can also be used, which is expected to be effective. Sometimes the antihistamine H 1 antagonist, such as cyproheptadine or chlorpheniramine combined with H2 antagonist, such as cimetidine, can often improve the curative effect. External use of emollient cream.