Thistle:
Another name
Wild safflower, small thorn cover, seaweed. Cirsium japonicum Cirsium japonicum Cirsium japonicum Sargassum japonica Cymbidium hybridum Sargassum japonica Rhododendron japonicum Japan wujia. Japan wujia. Japan wujia. Japan wujia. Japan wujia. Cynanchum multiflorum Thunb
Sexual taste, sweet, bitter and cold. Heart tropism and liver meridian.
Indications: cooling blood, stopping bleeding, removing blood stasis and reducing swelling. Used for epistaxis, hematemesis, hematuria, hematochezia and metrorrhagia.
Blood, traumatic hemorrhage, carbuncle, swelling and sore poison.
Usage and dosage: 4.5 ~ 9g. Appropriate amount of fresh products for external use, mashed and applied to the affected area.
Pharmacological action:
Effects of 1. on cardiovascular system
1. 1 exciting
The heart was prepared by Langendorff method with 200% Cirsium japonicum decoction and 200% ethanol extract decalcified by ammonium oxalate. The isolated rabbit heart and isolated guinea pig atrial muscle with adrenergic B 1 receptor were treated with 0. 1 ml water decoction and 0.05 ml alcohol extract.
1.2 booster function
Earlier years, it was reported that Cirsium japonicum decoction Ⅳ had a good effect of raising blood pressure, and had cardiotonic and vasoconstrictive effects, similar to catecholamine. Recently, Shandong Institute of Traditional Chinese Medicine isolated white Cirsium japonicum crystal from Cirsium japonicum soup. Ip0. 1% reserpine 0. 1ml/ 100g per day 100 days, so that catecholamine in rats is excreted, and reserpine rats are formed. Cirsium japonicum crystals were administered through femoral vein.
The results showed that Cirsium japonicum crystal ⅳ could obviously increase the blood pressure of rats without reserpine, and the pressor intensity was obvious, but the pressor effect on Cirsium japonicum crystal in rats with reserpine was obviously weakened, and its effect was similar to that of cold amine. At the same time, it is confirmed that its pressor effect is different from that of norepinephrine.
Effect of 1.3 on adrenergic receptors
The nutrient solution of 0.075g/ml Cirsium japonicum decoction has contractile effect on rabbit aortic strips of adrenergic A receptor, which can be antagonized by receptor blocker phentolamine. It has relaxing effect on isolated guinea pig tracheal slices with adrenergic β2 receptor, and can be antagonized by propranolol (0.0 1.7 mg/ml nutrient solution).
The effect of Cirsium japonicum decoction (0.0067g/ml nutrient solution) on atrial muscle is only110 of aortic strip and trachea slice, so it is considered that Cirsium japonicum has greater effect on adrenergic β 1 receptor than β2 receptor and α receptor.
2. Influence on blood system
Cirsium japonicum is a traditional Chinese medicine for hemostasis, which has been proved to have hemostatic effect and obtained effective components for hemostasis. Cirsium japonicum hemostasis mainly works by contracting local blood vessels and inhibiting fibrinolysis. Taking 5g/kg orally in mice can obviously shorten the bleeding time.
3. Anti-mutagenic effect
Ames test method, the concentrated solution was decocted twice with water, and the dosage of each dish was 3mg. The mutagen of TA98 is 4- nitroethylamine, and the restorer of TA 100 is sodium azide. The results showed that Cirsium japonicum was resistant to mutation.
4. Antibacterial effect
The decoction has certain inhibitory effect on hemolytic streptococcus, pneumococcus and diphtheria bacillus in vitro. When the alcohol soaking agent is 1:30000, it has inhibitory effect on human tuberculosis, but the inhibitory concentration of decoction on tuberculosis is more than 300 times.
5. Other functions
The decoction or tincture can stimulate rabbit uterus in vitro, in vivo and chronic fistula uterus, but inhibit cat uterus in vitro, rat uterus in vitro and rabbit small intestine in vitro. It is also similar to catecholamine. The decoction has no preventive and therapeutic effects on experimental carbon tetrachloride toxic hepatitis in rats. The glucose tolerance curve of rabbits with liver injury (carbon tetrachloride poisoning) can not accelerate its recovery. It seems to have a certain protective effect on arsenite poisoning in mice, but it is not very significant. It has certain anti-inflammatory effect on formaldehyde arthritis in rats, but it is not as good as cortisone. It has sedative effect on mice, but has no analgesic effect.