Because Fasciola brucei is mainly parasitic in the small intestine, the number can reach thousands, and may even spread to the stomach and large intestine. Generally speaking, only a few dozen species of Fasciola brucei parasitized in human body are adsorbed on intestinal mucosa to survive by blood, so patients will have abdominal pain, constipation, diarrhea, anemia and other symptoms alternately, while most patients with intestinal trematodes will hardly have obvious symptoms. In order to distinguish it from bacterial enteritis and amebic infection, we must rely on the examination of eggs in heavy feces or identify the adults who excrete and vomit. For the same large-scale clonorchiasis, it can be distinguished from the shape of testis, the ratio of two suction cups and the shape of the cone. Praziquantel can be used for treatment after diagnosis, and the general effect is good. In addition, some scholars suggested using other new drugs.