The first thing to note is that not all lipid-lowering drugs need to be taken at night.

According to the general scientific research results, the most closely related to cardiovascular and cerebrovascular malignant events is low density protein/cholesterol, which is not good cholesterol. All primary prevention and secondary prevention manuals strongly recommend low density protein/cholesterol as the index value for blood lipid reduction detection.

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The basic principle of the curative effect of statins is to inhibit the production of cholesterol, which is mostly carried out at night. Generally speaking, statins with short effective time in drug half-life are strongly recommended to be taken at night or before going to bed. Because if you take it at other times, the drug will not be effective when cholesterol production is the most abundant, and the practical significance of taking statins will be lost. Some scientific research has also confirmed this. The experiment found that the total cholesterol and low density lipoprotein cholesterol of simvastatin (drug half-life is relatively short) decreased more than that of simvastatin in the morning. But for these statins with a long history in drug half-life, there will be no such problem. For example, a small and medium-sized study of atorvastatin (drug half-life has a long history) found that there was no significant difference in the use of atorvastatin in the morning and evening.

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However, it is not convenient for patients to know which statins they are taking and how long drug half-life is, and it will not be convenient for many patients to remember. Therefore, we generally say that statins should be used before going to bed. After all, taking it before going to bed will not improve all other problems.